RESUMO
Background: inadequate control of type 2 diabetes mellitus patients consequently lead to the emergence of complications, like impairment of lipid profile and microalbuminuria. The main cause behind these events is the elevation in the oxidant stress process
Methods: this study was designed to evaluate the therapeutic utility of a novel formula which contain 75 mg zinc sulphate and 100 mg allopurinol, where 17 poorly controlled, type 2 diabetic patients were treated with a single daily dose of this formula, in addition to the regularly used oral hypoglycemic agents for 60 days
Results: obtained reflected a significant improvement in the blood glucose level [48% reduction], and microalbuminuria [60% reduction], associated with elevation of HDL-C levels [144%] and reduction of LDL-C levels [19%] compared with the per-treated values
Conclusions: the use of zinc sulphate and allopurinol may have an insulin mimetic activity which improve the glycemic control in inadequately controlled , type 2 DM patients according to a mechanism which require further extensive studies to be elucidated