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1.
Chinese Journal of Natural Medicines (English Ed.) ; (6): 850-854, 2020.
Artigo em Inglês | WPRIM | ID: wpr-881029

RESUMO

Three new mycophenolic acid derivatives, penicacids E-G (1-3), together with three known analogues, mycophenolic acid (4), 4'-hydroxy-mycophenolic acid (5) and mycophenolic methyl ester (6), were isolated from a marine-derived fungus Penicillium parvum HDN17-478 from a South China Sea marine sediment sample. The structures of compounds 1-3 were elucidated by HRMS, NMR, and Mosher's method. Among them, compounds 1 and 2 were the first examples of mycophenolic acid analogs with a double bond at C-3'/C-4' position. The cytotoxicity of 1-6 was evaluated against the HCT-116, BEL-7402, MGC-803, SH-SY5Y, HO-8910 and HL-60 cell lines, and compounds 4 and 6 showed potent cytotoxicity with IC

2.
Acta Pharmaceutica Sinica ; (12): 1275-1278, 2010.
Artigo em Inglês | WPRIM | ID: wpr-354527

RESUMO

A new sesquiterpene hydroquinone (1) was isolated from a deep sea sediment derived fungus, Phialocephala sp.. Its structure and stereochemistry were established on the basis of spectroscopic data and optical rotation. This compound was tested for cytotoxicity against P388 (murine leukemia cell) and K562 (human leukemia cell) cell lines, and displayed strong cytotoxic effects with IC50 value of 0.16 and 0.05 micromol x L(-1), separately.


Assuntos
Animais , Humanos , Camundongos , Antineoplásicos , Química , Farmacologia , Ascomicetos , Química , Linhagem Celular Tumoral , Sobrevivência Celular , Hidroquinonas , Química , Farmacologia , Concentração Inibidora 50 , Células K562 , Leucemia P388 , Patologia , Estrutura Molecular
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