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Chinese Pharmacological Bulletin ; (12): 857-862, 2018.
Artigo em Chinês | WPRIM | ID: wpr-705140

RESUMO

Aim To investigate the gene frequency of UGT1 A1?6 in cancer patients in Anhui Han popula-tion. Methods The 222 cases of blood samples of Han cancer patients were collected from different re-gions of Anhui province, and the UGT1A1?6 geno-types were detected by in situ hybridization fluorescencestaining. Results Patients with a UGT1A1?6 wild type ( GG ) accounted for ( 159 cases, 71. 62%) , which were higher than those of heterozygous mutations ( GA, 52 cases, 23. 42%) and of homozygous muta-tions ( AA, 11 cases, 4. 96%) of the total cases. The mutation rate of UGT1 A1?6 was 16. 67%, and partic-ularly in patients with esophageal cancer it was 43. 75%. The rates of mutation in the patients in Ma ' anshan and Chuzhou were 40. 01% and 34. 62%, re-spectively, both significantly higher than those of othertumors and regions. Conclusions Cancer patients in Anhui Han population have a high mutant frequency of UGT1 A1?6 . The UGT1 A1?6 genotyping can indi-rectly predict the risk of irinotecan's adverse reaction, which obviously enhances the potentially individualized treatment of irinotecan.

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