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OBJECTIVE@#To explore the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus after ovariectomy in mice.@*METHODS@#BDNF levels were detected by immunohistochemistry combined image analysis in hippocampal CA regions and dentate gyrus of ovariectomized mice.@*RESULTS@#The expression of BDNF in hippocampus of mice decreased significantly after the ovariectomy after 4 days. The recovery BDNF expression started 14 days after the ovariectomy and after 28 days, the expression of BDNF in hippocampus recovered to the normal level.@*CONCLUSION@#The decrease of estrogen in ovariectomized mice can weaken the expression of BDNF in hippocampus during the early stage.
Assuntos
Animais , Feminino , Camundongos , Fator Neurotrófico Derivado do Encéfalo , Genética , Giro Denteado , Metabolismo , Estrogênios , Sangue , Hipocampo , Metabolismo , Ovariectomia , RNA Mensageiro , GenéticaRESUMO
<p><b>OBJECTIVE</b>To discuss the anti-inflammatory mechanism of sinomenine on inflammatory media in joint of adjuvant arthritis rats.</p><p><b>METHOD</b>Rats were randomly divided into the normal group and the model group, the prednisone group, the small, medium, large of sinomenine group (30, 60, 120 mg x kg(-1)). Except for the rats in the normal group, animals were modeled to adjuvant arthritiswith freund's complete adjuvant. The arthritis index (AI) and the swelling degree of paws were recorded, and the activity of IL-1, TNF and the levels of NO, PGE2 in joint fluids of secondary arthritis were determined.</p><p><b>RESULT</b>Compared with the normal group, the activity of IL-1, TNF and the levels of NO, PGE2 in joint fluids of secondary arthritis were increased significantly in the model group (P < 0.05). Compared with the model group, it was shown to exert a dramatic inhibitory effect on secondary reaction of freund's adjuvant arthritis of rats, and the activity of IL-1, TNF and the levels of NO, PGE2 in joint fluids of secondary arthritis were significantly decreased in the sinomenine group (P < 0.05).</p><p><b>CONCLUSION</b>Sinomenine has a remarkable treatment effect on RA. It is via NO to inhibit the activity of cytokines and decrease the level of inflammation mediators, which may be one of its curing RA mechanism.</p>
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Animais , Masculino , Ratos , Anti-Inflamatórios não Esteroides , Usos Terapêuticos , Artrite Experimental , Tratamento Farmacológico , Dinoprostona , Metabolismo , Medicamentos de Ervas Chinesas , Usos Terapêuticos , Interleucina-1 , Metabolismo , Morfinanos , Usos Terapêuticos , Óxido Nítrico , Metabolismo , Fitoterapia , Distribuição Aleatória , Ratos Wistar , Sinomenium , Química , Líquido Sinovial , MetabolismoRESUMO
Objective:To study the effects of Taoist cognitive therapy on type A behavior of patients with coronary heart disease.Methods:206 patients with coronary heart disease were randomized divided into two groups. The study group received Taoist cognitive therapy for 3 months in addition to basic medical treatment.The control group was treated with medicine only.Both groups were followed for 6 months and evaluated with psychological scales,including Type A behavior scale,mental detachment scale.Clinical efficacy was also evaluated.Results:The score of type A had significant decreased from 25.8?7.6 to 20.8?5.8 after 3 months in the study group,the score of mental detachment significantly increased from 28.7?4.4 to 31.8?3.8(P
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This review summarizes the present advance of effects of stress on hippocampal structure and function and the role of hippocampus in feedback regulation of thalamic-pituitary-adrenocortical (HPA) axis during stress. It shows that stress can affect hippocampal structure and function, on the other hand, the hippocampus can also suppress the stress reaction through the feedback regulation of HPA axis, but chronic stress can attenuate this regulation, then significantly impair its structure and function.