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At present,the main treatment methods of the patients with advanced colorectal cancer include surgery,chemotherapy,radiotherapy,targeted therapy,physical ablation and immunotherapy,but the chemotherapy is still the main treatment.The emergence of new chemotherapy drugs and the combination of radiotherapy,chemotherapy and targeted therapy in clinical have improved curative effect for the patients with advanced colorectal cancer.In order to better improve the quality of life,reduce side effects and obtain the best effect,now the individual multidisciplinary treatment has become an inevitable trend in the treatment of advanced colorectal cancer in clinical.
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BACKGROUND: There is not any experimental model that can reflect the pathological change of hormone-induced avascular necrosis of the femoral head in a good way nowadays, which is unfavourable to the further observation of its pathogenesis. OBJECTIVE: The model of the avascular necrosis of the femoral head is induced by giving a large dose of dexamethasone into rabbits, which provides the animal experimental models for the study of clinical pathogenesis. DESIGN, TIME AND SETTING: The randomized controlled animal experiment was performed at the Animal Laboratory, Affiliated Hospital of Anhui Medical University from June 2004 to August 2005. MATERIALS: Sixteen healthy adult New Zealand albino rabbits (50% female and 50% male), weighing 3.0-3.2 kg were selected for this study. Dexamethasone was provided by Jiangsu Lianshui Medical Co., Ltd. etalon: 5 g/L. METHODS: Rabbits were randomly divided into two groups: model and control groups. Dexamethasone of 2.5 mg/kg per day was injected into each rabbit of the model group, and saline of 2 mL was injected into each rabbit of the control group for 6 weeks. MAIN OUTCOME MEASURES: Serum lipid and prothrombin time (pt) were tested before and after the experiment, and the histopathological change was observed with radiography, optical microscrope and transmission electron microscopy at 2, 4 and 6 weeks of dexamethasone administration. RESULTS: Compared with the control group, in the model group cholesterin levels were significantly increased at 2 weeks (P
RESUMO
The left clavicle of a healthy female was scanned by CT and serial sections were obtained. The CT images were fed into the Mimics and Ansys 10.0 software to construction a three-dimensional and finite element modeling of clavicle. Through meshing, assigning the material attribution, restricting the freedom and stimulating loading which effect to the vertical area of the acromion surface of clavicle, the result of stress and strain distribution and response of the model was obtained. Under the loading, the stress and strain mainly concentrated within the middle 1/3 part of the clavicle, and the stress on the superior surface was obviously highter than inferior surface. But the highest strain concentrated within the inferior surface of the middle 1/3 part of clavicle. The stress on superior surface of the middle 1/3 part of the clavicel was mainly tensile stress,or the inferior surface was compression stress. The stress and strain distribution didn't changed when the coracoclaviculare ligamenta was constructed. The result of finite element analysis of clavicle explains the reason why the middle 1/3 part of clavicle is prone to fracture, and the stress and strain distribution didn't changed when the coracoclaviculare ligamenta was constructed. Also, finite element analysis can be used to effectively understand the biomechanical characteristics of clavicle.