Effect of letrozole 2.5 mg or 5.0 mg for ovulation induction in intrauterine insemination in case of unexplained infertility: a randomized controlled trial

Background: Aim was to compare effects of letrozole 2.5 mg or 5.0 mg for ovulation induction in patients with unexplained Infertility. Methods: A randomized controlled trial. 60 patients attending infertility clinic were randomly allocated into two groups-Group A received letrozole 2.5 mg and Group B received letrozole 5 mg orally for 5 days from 3rd day of cycle. The patients also received inj FSH 75 IU i/m on day 7 and 9 of the cycle and underwent follicular study on day 11, 13, 15. When the dominant follicle size reached 18 mm ovulation triggered with Inj hCG 5000 IU IM and Intrauterine insemination was done 24-36 hours later. Pregnancy rates were calculated. Results were analysed by statistical software. Results: Better ovulation rates were seen in patients receiving 5 mg letrozole. No difference in the pregnancy rates was found between the two groups. No multiple pregnancies and ovarian hyperstimulation seen. Conclusions: It appears that 5 mg daily for 5 days is a preferable letrozole dose for superovulation.

Drotaverine to improve progression of labour among parturient women- a case control study

Background: Prolonged labour contributes to increased perinatal and maternal morbidity. Pharmacological interventions can hasten cervical dilation and help obstetrician to accomplish the delivery in the shortest possible time without compromising maternal and fetal safety. Aims and objectives were to evaluate the acceleration effect of drotaverine on the dilatation of the cervix in both primigravidae and multigravida and compare it with control group.Methods: A total of 70 patients were studied (35 in drotaverine group and 35 in control group). The inclusion criteria were pregnancy with at least 37 weeks completed, cervical dilatation 3-4 cm, regular uterine contractions and cephalic presentation. The study group received 40 mg drotaverine hydrochloride i.m. in active phase of labour, control group received standard delivery care. Parameters such as duration of first and second stage of labour, mode of delivery, neonatal outcome and side effects to drug was recorded.Results: 6 subjects from the study group and 4 from the control group developed complications in first stage of labour and were taken up for operative delivery and hence they were excluded from calculation of various labour parameters. The mean rate of cervical dilatation with drotaverine was 2.26 cm/hour, while it was 1.67 cm/hour without any intervention (p value <0.05). Mean duration of active phase of first stage of labor was 3.09 hours in drotaverine group against 4.98 hours in study group (p value <0.05). There were no significant untoward effects noted in either of the groups.Conclusions: Drotaverine was found to be an effective and safe drug in shortening the duration of the first stage of labor without any significant detrimental effects on the mother and newborn. Drotaverine did not interfere with uterine contractility and there was no increased incidence of operative deliveries.

Drotaverine to improve progression of labour among parturient women- a case control study

Background: Prolonged labour contributes to increased perinatal and maternal morbidity. Pharmacological interventions can hasten cervical dilation and help obstetrician to accomplish the delivery in the shortest possible time without compromising maternal and fetal safety. Aims and objectives were to evaluate the acceleration effect of drotaverine on the dilatation of the cervix in both primigravidae and multigravida and compare it with control group.Methods: A total of 70 patients were studied (35 in drotaverine group and 35 in control group). The inclusion criteria were pregnancy with at least 37 weeks completed, cervical dilatation 3-4 cm, regular uterine contractions and cephalic presentation. The study group received 40 mg drotaverine hydrochloride i.m. in active phase of labour, control group received standard delivery care. Parameters such as duration of first and second stage of labour, mode of delivery, neonatal outcome and side effects to drug was recorded.Results: 6 subjects from the study group and 4 from the control group developed complications in first stage of labour and were taken up for operative delivery and hence they were excluded from calculation of various labour parameters. The mean rate of cervical dilatation with drotaverine was 2.26 cm/hour, while it was 1.67 cm/hour without any intervention (p value <0.05). Mean duration of active phase of first stage of labor was 3.09 hours in drotaverine group against 4.98 hours in study group (p value <0.05). There were no significant untoward effects noted in either of the groups.Conclusions: Drotaverine was found to be an effective and safe drug in shortening the duration of the first stage of labor without any significant detrimental effects on the mother and newborn. Drotaverine did not interfere with uterine contractility and there was no increased incidence of operative deliveries.

A prospective randomized controlled trial to study the effect of prenatal yoga on maternal weight gain and psychological stress in pregnancy and its association with pregnancy outcomes

Background: Objective of study was to evaluate the effect of prenatal yoga on maternal gestational weight gain (GWG) and psychological stress in pregnancy (PSS) and to evaluate the effect of prenatal yoga on labour outcomes.Methods: Prospective randomized controlled trial conducted at AIIMS, New Delhi between May 2020-December 2021. Sixty women each were recruited in the yoga and control group. Women in the yoga group attended 60 minutes supervised yoga sessions followed by self-sessions. Women in the control group received routine antenatal care along with 30 minutes per day of walking and dietary counselling. The assessment was done for the weight(WT), dietary intake (D) and perceived stress score (PSS) at the time of recruitment (WT1, D1, PSS1), 28 weeks (WT2, D2, PSS2) and 36 weeks (WT3, D3, PSS3) and the results were then compared.Results: At recruitment all the parameters in both groups were comparable. The difference in mean and difference in percentage in terms of gestational weight gain (GWG) at recruitment and at 36 weeks was statistically significant (p-value=0.027). The per cent weight gain in the Yoga group was significantly low (p value=0.048). The control group experienced more amount of stress both at 28 weeks (p-value = 0.021) and 36 weeks (p-value <0.0001). The difference in mean and difference in percentage in terms of PSS1 and PSS2 (p-value=0.011), PSS2 and PSS3 (p-value=0.0001) PSS1 and PSS 3 (p-value=0.0001). Labour outcomes were comparable between both groups.Conclusions: Yoga helps in controlling excessive GWG and helps prevent many adverse feto-maternal outcomes associated with obesity.

Fetomaternal outcome among elderly gravida and normal age group mothers

Background: Advanced maternal age is defined as 35 years or more at estimated date of delivery is considered to have higher incidence of obstetric complications and adverse pregnancy outcome than younger women. Maternal age plays a vital role in pregnancy outcome. This study is instituted with the idea of identifying the association of advanced maternal age and adverse pregnancy outcome. Objective was to compare demographic characteristics and maternal outcome in elderly pregnancy in comparison with normal age group pregnancy. To compare perinatal outcome of elderly pregnancy with normal age group pregnancy.Methods: This was comparative case control study conducted at department of obstetrics and gynecology, Tirunelveli medical college hospital in 100 patients, about 50 in each of the 2 groups with maternal age > 35years and < 35 years. A group 1 (study group) was pregnant women of age >35 years and group 2 was pregnant women of age >18 years and<35 years. Pregnant women of age< 18 years and pregnant women having major medical disorders before pregnancy were excluded from study.Results: Among the study group incidence of artificial conception; spontaneous abortion; overt diabetes; chronic hypertension; preeclampsia; gestational hypertension ; fetal complications like FGR; shoulder dystocia were statistically significant.Conclusions: This study concludes that there is raised maternal morbidity and operative interventions needed with increasing age. Close monitoring for any complications is vital as early diagnosis and intervention will bring an excellent maternal and fetal outcome.

A prospective randomized controlled trial to study the effect of prenatal yoga on maternal weight gain and psychological stress in pregnancy and its association with pregnancy outcomes

Background: Objective of study was to evaluate the effect of prenatal yoga on maternal gestational weight gain (GWG) and psychological stress in pregnancy (PSS) and to evaluate the effect of prenatal yoga on labour outcomes.Methods: Prospective randomized controlled trial conducted at AIIMS, New Delhi between May 2020-December 2021. Sixty women each were recruited in the yoga and control group. Women in the yoga group attended 60 minutes supervised yoga sessions followed by self-sessions. Women in the control group received routine antenatal care along with 30 minutes per day of walking and dietary counselling. The assessment was done for the weight(WT), dietary intake (D) and perceived stress score (PSS) at the time of recruitment (WT1, D1, PSS1), 28 weeks (WT2, D2, PSS2) and 36 weeks (WT3, D3, PSS3) and the results were then compared.Results: At recruitment all the parameters in both groups were comparable. The difference in mean and difference in percentage in terms of gestational weight gain (GWG) at recruitment and at 36 weeks was statistically significant (p-value=0.027). The per cent weight gain in the Yoga group was significantly low (p value=0.048). The control group experienced more amount of stress both at 28 weeks (p-value = 0.021) and 36 weeks (p-value <0.0001). The difference in mean and difference in percentage in terms of PSS1 and PSS2 (p-value=0.011), PSS2 and PSS3 (p-value=0.0001) PSS1 and PSS 3 (p-value=0.0001). Labour outcomes were comparable between both groups.Conclusions: Yoga helps in controlling excessive GWG and helps prevent many adverse feto-maternal outcomes associated with obesity.

Fetomaternal outcome among elderly gravida and normal age group mothers

Background: Advanced maternal age is defined as 35 years or more at estimated date of delivery is considered to have higher incidence of obstetric complications and adverse pregnancy outcome than younger women. Maternal age plays a vital role in pregnancy outcome. This study is instituted with the idea of identifying the association of advanced maternal age and adverse pregnancy outcome. Objective was to compare demographic characteristics and maternal outcome in elderly pregnancy in comparison with normal age group pregnancy. To compare perinatal outcome of elderly pregnancy with normal age group pregnancy.Methods: This was comparative case control study conducted at department of obstetrics and gynecology, Tirunelveli medical college hospital in 100 patients, about 50 in each of the 2 groups with maternal age > 35years and < 35 years. A group 1 (study group) was pregnant women of age >35 years and group 2 was pregnant women of age >18 years and<35 years. Pregnant women of age< 18 years and pregnant women having major medical disorders before pregnancy were excluded from study.Results: Among the study group incidence of artificial conception; spontaneous abortion; overt diabetes; chronic hypertension; preeclampsia; gestational hypertension ; fetal complications like FGR; shoulder dystocia were statistically significant.Conclusions: This study concludes that there is raised maternal morbidity and operative interventions needed with increasing age. Close monitoring for any complications is vital as early diagnosis and intervention will bring an excellent maternal and fetal outcome.

Anthropometry of deep-set eyes with respect to difficulty in docking during femtosecond laser procedures

Purpose: To identify the facial anthropometric parameters that predict the difficulty during femtosecond (FS) laser. Methods: This was a single?center observational study was conducted on participants between the ages 18 and 30 years who were planned for FS?LASIK (femtosecond laser?assisted laser in situ keratomileusis) or SMILE (small incision lenticule extraction) at Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India. The front and side?facing images of the participants were analyzed using Image J software to measure different anthropometric parameters. The nasal bridge index, facial convexity, and other parameters were measured. The difficulty faced by the surgeon during docking was recorded for each subject. The data were analyzed on Stata 14. Results: A total of 97 subjects were included. The mean age was 24 (±7) years. Twenty?three (23.71%) subjects were females while the rest were males. Difficulty in docking was seen in 1 (4.34%) female and 14 (19%) males. The mean nasal bridge index was 92.58 (±4.01) in subjects with deep?set eyes and 89.72 (±4.30) in normal subjects. The mean total facial convexity was 129.28 (±4.24) in deep?set eyes, and 140.23 (±4.74) in normal subjects. Conclusion: Total facial convexity appeared as the most important feature, with the value being less than 133° in most subjects with unfavorable facial anthropometry

Obstetric hysterectomy in a tertiary centre: a 3-year retrospective study

Background: Obstetric hysterectomy (OH) is a life-saving procedure and involves removal of uterus in cases of intractable hemorrhage. This study includes 21 cases of OH in a period of 3 years at a tertiary centre. We sought to understand the prevalence, indications and outcomes of emergency obstetric hysterectomy.Methods: This is a retrospective, observational study, conducted with the means of hospital delivery records in a tertiary care centre in Navi Mumbai. We included all patients who underwent obstetric hysterectomy in a span of 3 years between 1st April 2020 to 31st March 2023, in Dr. D.Y. Patil Hospital, Navi Mumbai, India.Results: Twenty- one OH were done in the period of study. The incidence of obstetric hysterectomy was 0.45% (452 OH per 100,000 deliveries). It was more prevalent in patients with caesarean section compared to vaginal delivery. Women between the age 25-35 years group comprised of 57.15% cases. Out of the 21 women in the study 7 women were primigravida (33.33%). Most common cause for OH was observed to be uterine atony (42.85%) followed by adherent placenta (28.57%). Maternal morbidity like admission to intensive care unit and need for blood and blood product transfusion was noted in most patients, mortality was observed in only 1 case. Neonatal mortality was nil in this study but, admission to neonatal intensive care unit was required in 7 patients.Conclusions: Although, obstetric hysterectomy kills the future reproductive prospect for a woman, it is life saving for her. Timely decision for OH can not only prevent mortality but, also morbidity for the woman. Previous caesarean section and multigravida have higher incidence of OH. Atonicity is the predominant cause for obstetric hysterectomy in this study.

Optimization and evaluation of tear protein elution from Schirmer’s strips in dry eye disease

Purpose: Extraction of tear protein from Schirmer’s strip is a prerequisite for the proper identification and screening of biomarkers in dry eye disease. The study compares different methods of extraction of tear proteins from the Schirmer’s strip. Methods: Reflex tear was collected from healthy controls (HC; n = 12), Stevens–Johnson syndrome (SJS; n = 3) and dry eye disease (DED; n = 3) patients using capillary tube. This tear was used to measure the volume absorbed by Schirmer’s strip per microliter. Different buffers (6) were used to compare the protein yield from the Schirmer’s strip in four different conditions. The tear proteins extracted using the highest protein yield buffer were analyzed by mass spectrometry. Results: A linear relationship between the tear volume and wetting length was observed (r = 0.0.997, n = 6). The highest yield was observed after incubation of the Schirmer’s strip in 100 mM ammonium bicarbonate (ABC) with 0.25% Nonidet P?40(NP?40) at 4°C for an hour (P < 0.00005). The in?solution digestion of tear eluted in the above condition 100 Mm ABC + 0.25% NP?40 with one?hour incubation yielded a total of 2119 proteins in HC, SJS, and DED. The unique protein observed in SJS and DED was 0.6% and 17.9%, respectively. The significantly expressed proteins are associated with innate immune response, proteolysis, wound healing, and defense response. Conclusion: A method for extraction of protein from Schirmer’s strip was optimized for increase in protein yield from the tear sample. SJS and DED tear samples have unique protein signature. The study will aid in better design of tear protein?based experimental study.

Comparison of intravenous tranexamic acid versus sublingual misoprostol in reducing blood loss in patients undergoing caesarean section-an analytical observational study

Background: Preventing postpartum haemorrhage using uterotonics or other antifibrinolytic drugs is need of the hour among women undergoing caesarean section (CS). This study is to compare the effectiveness of intravenous Tranexamic acid versus sublingual misoprostol in reducing blood loss by assessing intraoperative and postoperative blood loss in patients undergoing CS.Methods: Analytical observational study was conducted in department of obstetrics and gynaecology at sri Devaraj URS medical college, among 118 pregnant women admitted for CS. Study was conducted between January 2020 to June 2021. The sample was divided equally into intravenous tranexamic acid and sublingual misoprostol groups. Number of mops, pads soaked, suction volume excluding the amniotic fluid, preoperative and post-operative haemoglobin, any complication were recorded.Results: The mean of mops counts in the misoprostol, TXA group were noted as 4.73�27, 3.2�45 respectively. Around 8.47% of the participants in the misoprostol group required uterotonics, whereas, 15.25% in the TXA group required uterotonics. The preoperative and postoperative haemoglobin in misoprostol group were identified as 11.67�37, 10.78�12 respectively, whereas it was identified as 11.76�43, 11.17�4 in TXA group. The common side effects identified in the misoprostol group was chills, vomiting and fever with 47.46%, 13.56% and 11.86% while, it was 11.86%, 5.08% and 3.39% in the TXA group.Conclusions: Both intravenous tranexamic acid, sublingual misoprostol could be prescribed as standard therapy to significantly control blood loss and increase the quality of surgery with better outcomes. But the use of TXA proved slightly better as there were lesser side effects and significantly lesser blood loss in uncomplicated cases.

Papillomacular bundle sparing versus conventional internal limiting membrane peeling for idiopathic macular hole ?400 µm

Purpose: To compare the outcomes of papillomacular bundle (PMB) sparing internal limiting membrane (ILM) peeling (group LP) and conventional ILM peeling (group CP) for treatment of idiopathic macular hole (MH) of ?400 ?m. Methods: Fifteen eyes were included in each group. In group CP, conventional 360° peeling was done, while in group LP, ILM was spared over PMB. The changes in peripapillary retinal nerve fiber layer (pRNFL) thickness and ganglion cell?inner plexiform layer (GC?IPL) thickness were analyzed at 3 months. Results: MH was closed in all with comparable visual improvement. Postoperatively, retinal nerve fiber layer (RNFL) was significantly thinner in the temporal quadrant in group CP. GC?IPL was significantly thinner in the temporal quadrants in group LP, whereas it was comparable in group CP. Conclusion: PMB sparing ILM peeling is comparable to conventional ILM peeling in terms of closure rate and visual gain, with the advantage of less retinal damage at 3 months.

Assessing the Anatomical Variations of Lingual Foramen and its Bony Canals with CBCT taken from 120 Patients

Introduction: The lingual foramen is situated in the midline, level with or superior to the genial tubercles. It contains blood vessels that supply the anterior mandible. This study was conducted with aim of assessing the anatomical variations of lingual foramen & its bony canals with Cone Beam Computed Tomography imaging within the local population.Also,to evaluate the correlation between various measurements taken with Age and Sex. Material and methods: This retrospective radiographic study was conducted in the department of oral medicine and Radiology, Govt Dental College & Hospital, Srinagar which included 120 patients (60 males and 60 females). Their CBCT were subjected to various measurements in cognizance with objectives of the study.Radiographic types and morphometric measurement were recorded. Radiographically subtypes of lingual foramen were recorded according to classifation given by Sekerci AE(2014) Results: In our study, all 120(100%) patients showed median lingual foramen, some patients also showed paramedian position (4 males and 3 females) Double lingual foramen (55.8%) is shown in most of the cases followed by single foramen (38.3%) .There was significant difference between gender seen in single lingual foramen (p-value 0.024). Type I lingual foramen was most (33.3%) commonly found followed by type VI(30.85%) Conclusion: There is wide range of anatomical variation of lingual vascular canals in respects of number, position and dimension.CBCT is a three-dimensional radiographic imaging modality with greatly reduced doses of radiation and high accuracy.Results will be discussed in detail in presentation.

A Conceptual Study on Deerghayu According to Classics

“Life well spent is long”, is well stated by Leonardo Da Vinci. A person's quality of life throughout all of those years of survival, rather than how many years they live, is what defines a long-life span. Superior constitution, great bodily components, excellent soul, adoption of a wholesome diet, and living a healthy lifestyle are the factors of this longevity. The lifespan of the individual should be checked by the doctor before any other aspects such as ailment, season, bio-fire, age, mental agility, homologation, constitution, medication, and location are examined. The attributes of Deerghayu that is long life span, along with Aahara (eating habits) and vihara (routines) to preserve longevity of life with the highest quality, have been outlined by Acharya Charaka after the Namakarana (naming ceremony) and Sushruta in Jatisutriya adhyaya in their description of life span. The present study analyzes the characteristic features of Deerghayu and the maintenance of these characteristics playing an important role in a long and healthy life.

Avoiding granulations and accidental decannulation in paediatric tracheostomy

Tracheal access, accidental deccannulation, peristomal granulation, stenosis and difficult weaning are the laryngologist’s dilemma, wherever tracheostomy has been resorted to, in the paediatric age group. These major problems necessitate a modification in the procedure of tracheostomy where ‘stay’ and ‘maturation’ sutures are utilized. The stay sutures facilitate a quick midline tracheotomy and the maturation ones minimise parastomal granulation and easy tracheal recannulation.

Indian Traditional Treatments for Psoriasis: A Critical Appraisal of Available Evidence Supporting Efficacy / 中国结合医学杂志

OBJECTIVE@#To examine data from studies supporting the clinical efficacy of medical approaches from India traditional systems of medicines like Ayurveda, Unani, Siddha, and Homeopathy for psoriasis using outcome indicators employed in clinical practice and research.@*METHODS@#Searches were conducted between December 2019 and September 2020 in databases PubMed, Scopus, Web of Science and Ovid Medline using search terms including traditional, complementary, psoriasis, Kushtha, Ayurveda, Siddha, Unani, Homeopathy and clinical. Controlled trials, case series and case reports published from India were included.@*RESULTS@#Data of 17 selected studies were extracted. Treatment efficacy in terms of improvement in Psoriasis Area and Severity Index (PASI) score or/and percentage reduction in score (PASI 50, PASI 75 and PASI 90) or/and patient-reported outcomes using instruments like Dermatology Life Quality Index and Psoriasis Disability Index were noted. All studies reported good improvement as per the study specific outcome. However, study characteristics, including study design, sample size, follow-up period, inclusion and exclusion criteria were heterogeneous, and the choice of outcome measures was not adequate to conclude the effectiveness of intervention. The use of some herbs as common ingredients in several formulations across different systems of medicines were noted in analyzing individual formulation.@*CONCLUSIONS@#Future studies must incorporate a comprehensive study design with specific outcome measures like PASI, PASI 75, PASI 90, quality of life parameters, compliance to medications, adverse reactions, remission period, relapse rate and cost-effectiveness with long term follow-up. The currently available evidence on the roles of these herbs at molecular level in psoriasis is preliminary.

COVID-19 Related Knowledge, Attitude, Practice Evaluation among Indian Dental Patients: A Cross-Sectional Survey

ABSTRACT Objective: To assess the awareness about COVID-19 among dental patients and determine the association between COVID-19 awareness and perceived stress among dental patients. Material and Methods: A selfadministered knowledge, attitude and practices (KAP) questionnaire and perceived stress scale (PSS) were employed to assess the knowledge and attitude among dental patients visiting the outpatient department. A p-value of ≤ 0.05 was considered statistically significant. An independent t-test was used to compare the KAP and PSS scores based on age, gender, occupation and the responses to unscorable questions. Spearman's correlation was employed to assess the association between KAP and PSS scores. Results: The older participants (mean KAP score = 16±2.2), the participants who answered that the Coronavirus outbreak changed their daily routine (mean KAP score = 15.8±2.2) and the participants who answered that they changed their plans due to the Coronavirus outbreak (mean KAP score = 16±2.14) had significantly higher KAP scores when compared to their respective counterparts. The Spearman's correlation value of -0.45 suggested a moderate negative association between the KAP and PSS scores, but this correlation was not statistically significant. Conclusion: The participants had a moderate to good level of knowledge related to COVID-19 and were positive in their approach and outlook on overcoming the pandemic.

Morphological characterization of subretinal hyper-reflective material in posterior uveitis using swept-source optical coherence tomography and optical coherence tomography angiography

Purpose: To analyze the structural features of subretinal hyper-reflective material (SHRM) in posterior uveitis using swept-source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (SS-OCTA). Methods: In this observational study, subjects with quiescent posterior uveitis and the presence of SHRM on SS-OCT were subjected to SS-OCTA to identify the presence of an intrinsic choroidal neovascular (CNV) network. OCT features were compared for SHRM harboring CNV (vascular SHRM) with those without CNV network (avascular SHRM) to identify clinical signs pointing toward the presence of CNVM inside SHRM. Results: Forty-two eyes of 33 subjects (18 males; mean age: 29.52 ± 12.56 years) were evaluated. Two-thirds (28/42) of eyes having SHRM on SS-OCT harbored intrinsic neovascular network (vascular SHRM). Increased reflectivity of SHRM (P < 0.001) and increased transmission of OCT signal underlying SHRM (P = 0.03) were suggestive of the absence of CNVM. The presence of intra/subretinal fluid (P = 0.08) and pitchfork sign (P = 0.017) were important markers of vascular SHRM. Conclusion: SHRM is an important OCT finding in eyes with posterior uveitis. Meticulous assessment of SHRM characteristics on SS-OCT can aid in identifying the underlying intrinsic neovascular network.

North India Childhood Cataract Study - The real scenario and causes of surgical delay of pediatric cataract

Purpose: The study sought to describe the clinical presentation pattern of pediatric cataracts and factors leading to delay in surgery at a tertiary care center in North India. Methods: A cross?sectional, interview?based study was conducted from January 2020 to October 2020, that included pediatric patients <12 years, with unilateral or bilateral congenital or developmental cataract. A pre?validated questionnaire was used to record data. The parameters recorded were age at first symptoms, age at diagnosis of cataract, age at surgery, laterality of cataract, first symptom, first family member noticing the abnormality, the morphology of cataract, association of perinatal complications, family history, systemic diseases, and cause (s) of delay in surgery. Results: A total of 89 patients were included. The mean age of subjects was 4.75(±3.51) years. A white pupil was the most common symptom (64.04%) and appeared in infancy in 30.3% of cases. Parents first detected the problem in 60.67%, and the pediatrician was the first medical contact in 11.23% of cases. The median (IQR) delay period between diagnosis of cataract and cataract surgery was 4 (3–6) months, the major causes were long GA waiting (30.33%), and delay due to systemic ill health (14.61%). Conclusion: Parental education on cataract detection is recommended to help in the timely detection and hence, improved outcomes of pediatric cataract surgery. Pediatricians, consulted for any systemic illness, have the role of the second most important contact in the detection of pediatric cataract.

A Brief Review on Tejovati (Zanthoxyllum Armatum.Dc.) in Vedas and Samhita: An Ethnomedicinally Rich Plant

Medicinal plants are considered as a rich resources of ingredients which can be used in drug development either pharmacopoeial, non- pharmacopoeial or synthetic drugs. A part from that, these plants play a critical role in the development of human cultures around the world. Traditional Indian medicine (Ayurveda) is becoming increasingly popular, with many chronic conditions responding to it well. Most patients begin to take conventional medications as soon as their diagnoses are made, so Ayurvedic treatments are usually undergone alongside and/or after conventional medical approaches. WHO (World Health Organization) estimated that 80 percent of people worldwide rely on herbal medicines for some aspect of their primary health care needs. According to WHO, around 21,000 plant species have the potential for being used as medicinal plants. Elaborate description of the plant and its therapeutic action are explained by our Acharyas in Vedas, Puranas, and Samhitas and in the later Nighantus. Tejovati is such a drug which is widely available and is having many mentioning in the classics for its effectiveness in many diseases. Tejovati does not have any controversies in any of the literatures or classics regarding its identification or usage. The current article is to highlight the importance of drug and references has been collected from Vedas, Puranas, Samhita kala, Nighantu kala. Synonyms, Gana Varga, Vernacular names etc has been collected and arranged systematically.