RESUMO
Objective To further confirm the clinical value of serum total bile acid (TBA) in hepatic lesion in patients with hemolytic disease of the newborn.Methods Enzyme circulation assay was applied to measuring in 68 patients with hemolytic disease of the newborn. Total bilirubin (TBIL), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and γ-glutamyltransferase (GGT) were measured simultaneously.Results The serum level of TBA was (27.63±4.83) mmol/L in haemolysis group, significantly higher than that in control group (14.92±6.87) mmol/L (P<0.01). The positive rate accounted for 70.59% (48/68) in haemolysis group, and serum level of TBA was positively correlative with liver functional parameters (TBIL, ALT, GGT and ALP).Conclusion Serum TBA may be used as an indicator of therapeutic effect monitoring and prognosis evaluation of hepatic lesion in patients with hemolytic disease of the newborn.