Assay of antigens with anti-lung cancer McAb 3C_9 and preliminary evaluation of serological diagnosis for lung cancer / 第三军医大学学报

The antigens(3C9Ag)which could be recognized by the anti-lung cancer monoclonal antibody 3Ca were assayed with BA-ELISA immunobinding inhibition test in 50 lung cancer patients,21 patients with non-cancerous pulmonary diseases and 40 normal subjects.Meanwhile radioimmunoassay was used to determine serum CEA.It was found that the sensitivity,specificity and accuracy for 3C9Ag to diagnose lung cancer were 76%,90.5% and 80.3% respectively.Much higher positive rates could be found in NSCLC patients and in those with stage Ⅱ or Ⅲ cancer.3CsAg was superior to CEA in its sensitivity and accurracy.Combined assay with 3C9Ag and CEA could increase the positive rate.

Determination of DNA content in Different Human Lung Cancerswith Microspectrophotometer / 第三军医大学学报

The DNA contents of 39 surgically resected specimens of different histopa-thological kinds and types of human lung cancer were determined with microspec-trophotometer. Among them, 3, 6, and 5 cases were diagnosed as well, moderately and poorly differentiated squamous cell carcinoma; 3,5, and 5 as well, moderately and poorly differentiated adenocarcinoma; and 3 and 6 cases as large and small cell types of undifferentiated carcinoma respectively.It was found that the DNA contents of different histopathological kinds and types of lung cancers were significantly different(P