Placental site trophoblastic tumor.

Placental site trophoblastic tumor is very rare. It is a gestational trophoblastic neoplasm which follows normal or molar pregnancy. It is usually confined to uterus & 15-20% behave in a malignant fashion. Clinically patients present with abnormal excessive bleeding or amenorrhoea. Though several trophoblastic lesions & tumors enter in the differential diagnosis, microscopically the diagnosis is usually straightforward in hysterectomy specimens. Hysterectomy is the treatment with or without chemotherapy. Progress after surgery should be monitored by placental lactogenic hormone.

Primary signet ring carcinoma of the large bowel--a case report.

Primary signet ring carcinoma of the colon and rectum is a rare neoplastic disease. The first case was reported by Laufman and Saphir in 1951. The patients have extensive disease at the time of diagnosis and the prognosis is extremely poor. Thus though difficult early diagnosis and curative operation are important.