RESUMO
Background: Diabetes mellitus (DM) is the most common non-communicable disease of the modern world. The study of plants having antihyperglycemic and hypolipidemic activities may give a new approach in the treatment of DM. The study was intended to evaluate the antihyperglycemic and hypolipidemic activity of ethanolic extract of Clerodendrum infortunatum Linn. (EECL) in alloxan-induced diabetic albino rats. Methods: Diabetes was induced in albino rats by administration of alloxan monohydrate (160 mg/kg, intraperitoneal). Rats were divided into six groups of six animals each. First group served as non-diabetic control, second group as diabetic control, third group as standard and was treated with 0.1 mg/kg/day of glibenclamide. Group 4, 5, and 6 received 200 and 400 mg/kg body weight of EECL. Blood samples were analyzed for blood glucose on day 1, 3, 7, 14, 21, and 28 and lipid profile on day 28. Results: The EECL showed a significant reduction (p<0.001) in blood glucose level and serum lipid profile levels with 400 mg/kg body weight in alloxan induced diabetic rats as compared with control. Conclusion: It is concluded that EECL is effective in controlling blood glucose levels and in improving lipid profile in diabetic rats.
RESUMO
Background: The current study evaluates the anti-infl ammatory activity of ethanolic extract of Cananga odorata Lam (EECO) in experimental animals. Methods: Acute toxicity test was done following OECD guidelines. Carrageenan induced paw edema method in Wistar Albino rats were used in this study. Aspirin in the dose of 300 mg/kg was used as the standard drug and three doses of EECO (100 mg/kg, 200 mg/kg and 400 mg/kg b.w. p.o) were used as the test drug. The results were measured at 1st hr, 3rd hr and 5th hr after carrageenan injection. Results: EECO in the doses of 100 mg/kg, 200 mg/kg and 400 mg/kg showed highly signifi cant anti-infl ammatory activity (p<0.001) (p<0.001) (p<0.001) at 3rd hr and (p<0.001) (p<0.001) (p<0.001) 5th hr, respectively. In doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg of EECO showed the percentage of inhibition of 62.9% which is more than the standard drug aspirin, which showed 60.14% inhibition. Conclusion: EECO has signifi cant anti-infl ammatory activity.