Plasma levels of interferon-inducible protein 10 in patients with active pulmonary tuberculosis with different affected areas / 南方医科大学学报

OBJECTIVE@#To explore the value of interferon-inducible protein 10 (IP-10) in the auxiliary diagnosis of tuberculosis and the judgment of the severity of disease.@*METHODS@#From February, 2013 to February, 2017, a total of 193 patients with TB admitted in our hospital and 84 healthy control subjects were recruited consecutively. The peripheral blood plasma levels of interferon-γ (IFN-γ) and IP-10 were detected using liquid phase chip (Luminex) technique. According to the number of lung fields affected by TB, the patients were divided into group A (with lesions in 1-2 lung fields), group B (3-4 lung fields) and group C (5-6 lung fields), The expressions of IFN-γ and IP-10 in 3 groups were compared.@*RESULTS@#The plasma levels of IP-10 were significantly higher in TB patients than in the control subjects ( < 0.05), but IFN-γ levels were comparable between the two groups ( > 0.05). Among the TB patients, plasma IP-10 levels was the highest in group C ( < 0.05), and IFN-γ levels did not differ significantly among the 3 groups ( > 0.05).@*CONCLUSIONS@#Plasma IP-10 has a certain reference value in the auxiliary diagnosis of active tuberculosis and the judgment of the severity of the disease.

The role of PCT and CPIS score in the diagnosis of active pulmonary tuberculosis complicated with ventilator associated pneumonia / 中华急诊医学杂志

Objective To explore the value of the variation of clinical pulmonary infection score (CPIS) and serum procalcitonin (PCT) in diagnosis and treatment evaluation in patients suffering from active pulmonary tuberculosis with complication of ventilator-associated pneumonia (VAP).Methods A retrospective analysis was carried out in 58 VAP patients from June 1,2009 to December 30,2014 in the respiratory intensive care unit.According to the patient suffering from tuberculosis or not,patients were divided into two groups.The PCT and CPIS score changes were observed in the two groups of patients with intra-tracheal intubation 1,3 and 7 days after VAP onset.Comparisons of CPIS and PCT scores were carried out between two groups at different intervals after VAP onset.Data were statistically processed by SPSS 19.0.Count data were tested by x2,and measurement data were expressed by mean ± standard deviation (x-±s).The comparison within the groups was made by t test,whereas the comparison between the groups was by means of repeated measure analysis of variance and Bonferroni test;Pearson linear correlation analysis was used,and P ＜ 0.05 was considered statistically significant.Results At the same observation interval in two groups of patients with VAP,there was no significant difference in the serum levels of PCT and CPIS score (P ＞ 0.05);there were significant differences in PCT and CPIS scores between VAP occurred at the first day,the third day and at time of intra-tracheal intubation in two groups (P ＜ 0.05).However,comparison of PCT and CPIS scores at the seventh day,the differences were not statistically significant (P ＞ 0.05).In addition,at the 7 days the correlation coefficient between PCT and survival patients' mechanical ventilation,days in ICU and total length of hospital stay were 0.92,0.83,and 0.71,respectively,yet the 7-day CPIS score correlation coefficients were 0.83,0.74 and 0.70,(both P ＜ 0.05).Conclusions Early monitoring of serum PCT and CIPS score of pulmonary tuberculosis patients can judge the incidence of VAP,and the variations of PCT and CIPS score can predict the severity and prognosis of the disease as well.

Distribution and drug-resistance of bacteria in the lower respiratory tract in patients with tuberculosis and severe pneumonia receiving invasive mechanical ventilation / 南方医科大学学报

<p><b>OBJECTIVE</b>To investigate the distribution and drug-resistance of bacteria in the lower respiratory tract in patients with tuberculosis and severe pneumonia receiving invasive mechanical ventilation.</p><p><b>METHODS</b>The clinical data, lower respiratory tract infection pathogens and bacterial drug sensitivity were analyzed in 208 patients receiving invasive mechanical ventilation for tuberculosis and severe pneumonia.</p><p><b>RESULTS</b>A total of 355 pathogenic microbial strains were obtained from the patients, among which 281 (79.2%) strains were Gram-negative bacteria, 62 (17.5%) were fungi, and 12 (3.4%) were Gram-positive bacteria. Mixed infections were found in 68 cases (19.2%). The sensitivity rates of meropenem, imipenem and amikacin were over 60% for Gram-negative bacteria, and those of teicoplanin, vancomycin, and fusidic acid were 100% for Gram-positive bacteria.</p><p><b>CONCLUSION</b>The main pathogenic bacteria are Gram-negative bacteria, fungi and Gram-positive bacteria in the lower respiratory tract of patients with tuberculosis and severe pneumonia receiving mechanical ventilation. Meropenem, imipenem and amikacin are effective antibiotics for lower respiratory tract infections, and multi-drug resistance is frequent in these patients, which urges appropriate use of the antibiotics.</p>

Ifosfamide/etoposide/carboplatin chemotherapy in the treatment of patients with advanced non-small cell lung cancer / 中国肺癌杂志

<p><b>BACKGROUND</b>To investigate the efficacy and toxicity of ifosfamide, etoposide, and carboplatin (IEC) regimen in the treatment of patients with advanced non-small cell lung cancer.</p><p><b>METHODS</b>Thirty-three patients with advanced non-small cell lung cancer were treated with IEC regimen, which consisted of ifosfamide 2.0g/m²(patients with age > 70 years: 1.3g/m²), IV D1-3; etoposide 130mg/m², IV D1-3; carboplatin 300mg/m², IV D1, repeated every four weeks.</p><p><b>RESULTS</b>Of the 33 patients, 7 cases got partial response, 24 had stable diseases, and 2 had progressive diseases, and the overall response rate was 21.2% (7/33,95% CI: 7.3% to 35.1%). The median survival and 1-year survival rate were 7.8 months (95% CI: 6.2 to 9.4 months) and 20.0%(95% CI: 6.0% to 34.0%) respectively. Main adverse effects were severe hematologic toxicities. The frequency of leukopenia,thrombocytopenia and anemia with grade III and grade IV was 51.5% (17/33), 18.2%(6/33) and 30.3%(10/33) respectively. There was significantly higher frequency of leukopenia (P=0.024) and thrombocytopenia (P=0.037) with grade III and grade IV in patients with age≥60 years than those with age < 60 years.</p><p><b>CONCLUSIONS</b>IEC is an effective regimen in the treatment of patients with advanced non-small cell lung cancer. Main adverse effects are severe hematologic toxicities, which are more significant in elderly patients. It is necessary to apply G-CSF or GM-CSF protection to avoid severe myelosuppression for elderly patients.</p>

Electrovaporization of human prostatic tissue in vivo / 中华泌尿外科杂志

Objective To investigate the effect of electrovaporization on prostatic tissue structure in vivo. Methods 26 cases of benign prostatic hyperplasia underwent electrovaporization of prostatic tissue,the surface area of the vaporized prostatic tissue and the depth at the central area being observed with light microscope and electron microscope. Results The vaporizing effect on tissue with pure cut current were stronger than that with pure coagulative current, the greater the output power the stronger the vaporizing effect.6 millimeter under the vaporized surface caused by pure coagulative current still revealed some histological alterations of injury,while these histological alterations in pure cut current electrovaporization was less. Conclusions These findings may have implications that in transurethral electrovaporization of prostate,injury to the adjacent or deep tissues should be avoided as much as possible.

Brief Discussing Medical Workers' Good Image in New Periods / 中国医学伦理学

Stressing discussion from the angle of medical morality, the paper expounds that medical workers should have a good image in new periods. It gives the opitions of how to build up a good image as well.

Influence of disease severity and antituberculosis treatment effectiveness on helper T-cells in peripheral blood from patients with pulmonary tuberculosis / 中国免疫学杂志

Objective:To explore the influence of disease severity and effectiveness of antituberculosis treatment on helper T-cells in peripheral blood from patients with pulmonary tuberculosis.Methods:Th1 cells and Th2 cells of peripheral blood of 62 pulmonary TB patients and 30 controls were marked by intracellular cytokine(INF-? and IL-4 representative of Th1 and Th2 subsets respectively) and counted by Flow Cytometry.The levels of Th1 and Th2 cell count from patients with different disease severities radiologically before antituberculosis therapy were compared and their correlation with effectiveness of different antituberculosis treatment radiologically was analyzed either.Results:The baseline levels of Th1 cell count and Th2 cell count in pulmonary tuberculosis group before antituberculosis therapy were significantly lower than those in the control group(P0.05,t test).The levels of Th1 cell count in the stable group were still significantly lower than those in the control group(P