RESUMO
Introduction@#Excess fat accumulation contributes to the development of type 2 diabetes mellitus (T2DM). Lipid accumulation product (LAP) is an index computed from waist circumference and triglycerides, which represents increased lipotoxicity. We aim to study the relationship of LAP index and T2DM and its utility as a predictor for T2DM development.@*Methodology@#A literature search in PubMed and Cochrane database was performed to retrieve and review studies reporting the association between LAP and T2DM@*Results@#Two cross-sectional studies from Japan and the United States, and one cohort study from Iran were obtained. A high LAP was associated with a higher risk of T2DM [odds ratio (OR) 19.1, 95% confidence interval (CI) (6.6-55.5) for women; and OR 7.4, 95% CI (5.1-10.8) for men].@*Conclusion@#LAP was strongly associated with T2DM. Its utility in predicting the development of T2DM needs to be confirmed.
Assuntos
Produto da Acumulação Lipídica , Diabetes Mellitus Tipo 2 , Resistência à Insulina , ObesidadeRESUMO
@#Untreated thyroid dysfunction during pregnancy increases morbidity in the mother and fetus. Anti-thyroid medication is the first-line therapy for hyperthyroidism during pregnancy. The diagnosis of thyroid dysfunction in pregnancy is complicated because of seemingly insignificant and non-specific symptoms which overlap with normal changes during pregnancy. Early detection and management should be done to prevent maternal and fetal complications.
Assuntos
Gravidez , Glândula Tireoide , Guia de Prática Clínica , IndonésiaRESUMO
@#Diabetes Mellitus (DM) in pregnancy has serious impact on both mother and baby if not optimally managed. The Indonesian Task Force on Reproductive Diseases determined that diabetes in pregnancy represents a priority area in need of updated evidence-based practice guidelines. The aim of the guidelines is to provide the best evidence-based recommendations for diagnostic evaluation and management of diabetes in pregnancy. The following article summarizes the guidelines.