RESUMO
Subacute dose of 0,0-diisopropyl phosphorofluoridate (DFP), a potent organophosphorus ester capable of producing delayed neurotoxicity (OPIDN), did not produce any significant change in the levels of lysosomal and mitochondrial marker enzymes of brain, liver and serum at any time after treatment in hens protected with atropine. The results suggest the absence of any involvement of mitochondrial and lysosomal enzymes at any stage in the development of OPIDN in susceptible species by treating with DFP.
Assuntos
Animais , Encéfalo/enzimologia , Galinhas , Isoflurofato/toxicidade , Lisossomos/enzimologia , Mitocôndrias/enzimologia , Mitocôndrias Hepáticas/enzimologia , Doenças do Sistema Nervoso/induzido quimicamenteAssuntos
Doença da Altitude/mortalidade , Animais , Hipóxia/prevenção & controle , Jejum , Glucose/farmacologia , Masculino , Ratos , Fatores de TempoRESUMO
The effect of exposure of albino rats to simulated high altitude stress of 5000 metres for 3 and 6 hrs on plasma transaminases, non-protein nitrogen (NPN), total protein percentages and blood sugar levels have been studied both with and without the administration of an anti-stress drug Imipramine HCl at 2.0 mg/kg body weight. The drug appears to have a slight hepatotoxic effect.