Comparisons between acute pulmonary edema induced by kainic acid microinfusion and by electrolytic lesion to the lateral preoptic area of the hypotalamus in rats To research for mechanism of neurogenic pulmonary edema / 中国病理生理杂志

The pulmonary edema produced by electrolytic lesions of the lateral pre optic area (POA) of the hypotalamus can be reproduced by kainic acid (KA) microinfused in the POA of rats. KA group and electrolytic group showed similar patterns of lung pathology on gross and microscopic examination. The arterial blood pressdre and the frequency of discharge from the greater splanchnic nerve in KA group was increased more severely than in electrolytic group.The data indicate that there is a special and close ralation between lesion of POA and development of pulmonary edema. They also suggest that the changes in hemodynamics may not be a major factor in mechanisms of neurog enic pulmonary edema.