Comparative quantitative analysis of fruit oil from Hippophae rhamnoides (seabuckthorn) by qNMR, FTIR and GC-MS / 中草药·英文版

OBJECTIVE@#To develop a qNMR method for quantitative analysis of triacylglycerols in fruit oil of Hippophae rhamnoides (seabuckthorn, SBT) and analyze commercial samples of SBT oils using GC-MS and FTIR.@*METHODS@#SBT fruit oil (IPHRFH) was extracted with hexane and the triglyceride (TAG) was isolated by vacuum liquid chromatography. Six different branded SBT oils purchased from e-commerce suppliers (Amazon) and in-house prepared SBT oil was analyzed by qNMR and fatty acyl composition of TAGs determined by using NMR. In-house oil was also analysed by GC-MS and FTIR spectroscopy.@*RESULTS@#The qNMR results showed that the oil contained 80.3% of triacylglycerol (TAG). The SBT oil TAGs comprised of linolenate 6.6%, palmitoleate/oleate 65.4%, and total saturated fatty acyl chain including palmitate 28% as determined by qNMR. GC-MS analysis revealed that the major acyl functionalities present in the TAG were palmitoleic acid 36.5%, oleic acid 12.9%, palmitic acid 21.2%, and linoleic acid 18%. Of the six commercial samples analyzed, samples from only one supplier (SW) were fruit oil; All others were the seed oils or mix of fruit oil and seed oil. The labels for samples except for the SW did not indicate whether it was fruit oil or seed oil.@*CONCLUSION@#The results suggest that SBT oil should be analyzed by combination of GC-MS, FTIR and qNMR for factual content of free fatty acid or TAGs, which are chemically different in nature and affect the quality of oil. GC-MS showed the content of omega free fatty acids after hydrolysis, while qNMR and FTIR showed the content of TAGs. The major acyl functionalities found in SBT fruit oil TAGs are palmitoleate/palmitate/oleate, while linoleate and linonelate make up a minor fraction. Furthermore, analysis of commercial samples showed discrepancies between label claims and actual content.

To study the prevalence of latent tuberculosis infection among medical students

Background: Risk of developing latent tuberculosis infection increases in medical students with their higher exposure to TB care facilities. Objective: To study the prevalence of latent TB infection among students attending professional degrees MBBS, BDS, MD, MS, MDS at King George’s Medical University, India. Methods: This study was carried out with Tuberculin skin testing among students and active TB cases were excluded. A standard dose of 0.1?mL of purified protein derivative was slowly injected intra dermally into non-dominant forearm. After 48-72 hours, the reaction was estimated by measuring the transverse diameter of the induration. Results: Total 561 students had given consent to get enrolled. Prevalence of latent tuberculosis infection was significant with period of clinical exposure (p-value < 0.05), average size of induration (p-value < 0.001), and history of prior Tuberculin Skin Test (p-value < 0.001). However it was not significant with the age (p-value > 0.05), gender (p-value > 0.05), and history of contact with active cases of TB (p-value > 0.05). Conclusion: The prevalence of latent tuberculosis infection is higher in post graduate students followed by interns and final year students due to more exposure to patients in wards and clinics at King George’s Medical University, India.

Vaccine Significantly Reduces the Severity of Covid 19 Infection: Evidence from a Community Based Study

Background: Coronavirus disease is an infectious disease caused by newly discovered coronavirus (SARS-CoV-2), which spread rapidly throughout the world. Vaccines will provide a lasting solution by enhancing immunity and containing disease spread. This study was conducted to find out vaccination status among Covid-19 positive patients and correlate severity of infections with vaccination status. Methodology: This cross sectional study was carried out among 1218 Covid-19 positive patients that were positive after the launch of Covid-19 vaccine, selected by purposive sampling method. Data was collected using pretested semi structured proforma. Results: Covid-19 vaccination coverage was very low (10.03%) in Covid-19 positive patients, for single dose it was 8.38% and for two doses it was 1.65%. Asymptomatic and mild cases were more in vaccinated compared to unvaccinated, it was statistically significant. Though hospitalization in vaccinated was less it was not significant. There was no death among vaccinated cases. Conclusion: Vaccination coverage were very low, this needs to improve. Vaccine was significantly reduces the severity of infection. It is recommended to vaccinate all eligible population as early as possible which will help in reducing severe and hospitalized cases and ultimately reducing the impact of Covid-19 pandemic.

Effect of poly-D-lysine on proliferation and senescence of caprine spermatogonial stem cells in vitro

Spermatogonial stem cells (SSCs) have the unique ability of both self-renewing and to produce progeny that undergoes differentiation to spermatozoa. As SSCs exist in very low numbers, therefore efficient in vitro expansion of SSCs is important prior to their clinical applications. In this study, we tried to improve the functionality of putative SSCs (pSSCs) during culture using poly-D-lysine (PDL) coating. For this, plates were coated with 0.01% PDL with different coating time interim treatments (5, 30 and 60 min) while control remained uncoated. The adequate amount of pSSCs of the goat was isolated and enriched using two-step enzymatic digestion and differential plating methods. Further, the functionality of pSSCs was evaluated by cell growth analysis, cell proliferation, senescence, and the presence of pluripotency (alkaline phosphatase, OCT-4) and SSC related (PGP-9.5) markers. The number and size of pSSCs colonies in 0.01% PDL coating groups were significantly (P <0.05) higher than in the control group. Similarly, pSSCs on uncoated plates expressed significantly (P <0.05) higher

Expanding the Clinical Spectrum of RFC1 Gene Mutations

Biallelic intronic repeat expansion in the replication factor complex unit 1 (RFC1) gene has recently been described as a cause of late onset ataxia with degeneration of the cerebellum, sensory pathways and the vestibular apparatus. This condition is termed cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS). Since the identification of this novel gene mutation, the phenotypic spectrum of RFC1 mutations continues to expand and includes not only CANVAS but also slowly progressive cerebellar ataxia, ataxia with chronic cough (ACC), isolated sensory neuropathy and multisystemic diseases. We present a patient with a genetically confirmed intronic repeat expansion in the RFC1 gene with a symptom complex not described previously.

Surviving complications of retroperitoneal fibrosis with intermittent relapses over a period of 20 years: case report and literature review / Sobrevivir a las complicaciones de la fibrosis retroperitoneal con recaídas intermitentes durante un período de 20 años: reporte de un caso y revisión de la literatura

Idiopathic retroperitoneal fibrosis is a rare fibro-inflammatory disease of varied etiology which usually originates around aorta and spreads caudally along Iliac vessels into adjacent retroperitoneum causing ureteral obstruction as the most frequent complication.A 53-year-old male patient presented with complaint of mild pain in both the legs off and on. On investigating further, we found that he had been struggling with intermittent relapses every 3-4 years for last 20 years since he was first diagnosed with Idiopathic Retroperitoneal Fibrosis. He was 33-year-old when he first developed the symptoms of anuria for 48 hours and was diagnosed with Idiopathic retroperitoneal fibrosis. This was followed by atrophy of left kidney and hypertension 6 years later, then hypothyroidism after another 3years and finally involvement of Inferior Vena Cava and acute Deep Vein Thrombosis of lower limbs after another 3-4 years. His deep vein thrombosis was well managed in time. He was put on glucocorticoids everytime he had a relapse and a complication.We did a review of literature to understand recent advances about its pathogenesis, diagnosis, investigations and management. We searched in PubMed using terms like retroperitoneal fibrosis alone and in combination with related terms such as Inferior Vena Cava thrombosis, Deep Vein Thrombosis, Tamoxifen, Methotrexate. This case is unique as it is very rare to find acute Deep Vein Thrombosis in Idiopathic retroperitoneal fibrosis without development of any collaterals when Inferior Vena Cava lumen is compromised to almost complete obstruction.After a follow up of 20 years patient is doing well in terms of physical activity and psychological wellbeing with anti-hypertensives, thyroxine and anti-coagulants. Is the disease-free interval actually free of the disease or it just subsided with immunosuppressants to become active after some time?

La fibrosis retroperitoneal idiopática es una enfermedad fibroinflamatoria rara, de etiología variada que generalmente se origina alrededor de la aorta y se propaga caudalmente a lo largo de los vasos ilíacos en retroperitoneo adyacente causando obstrucción ureteral como la complicación más frecuente.Reportamos el caso de un paciente varón de 53 años que se presentó con un dolor leve en ambas piernas. Al investigar más a fondo, descubrimos que había estado luchando con recaídas intermitentes cada 3-4 años durante los últimos 20 años desde que se le diagnosticó por primera vez fibrosis retroperitoneal idiopática. Tenía 33 años cuando desarrolló por primera vez los síntomas de anuria durante 48 horas y se le diagnosticó fibrosis retroperitoneal idiopática. Esto fue seguido por atrofia del riñón izquierdo e hipertensión 6 años después, luego hipotiroidismo después de otros 3 años y finalmente afectación de la vena cava inferior y trombosis venosa profunda aguda de las extremidades inferiores después de otros 3-4 años. Su trombosis venosa profunda se controló bien a tiempo. Le recetaron glucocorticoides cada vez que tenía una recaída y una complicación.Hicimos una revisión de la literatura para comprender los avances recientes sobre su patogenia, diagnóstico, investigaciones y manejo. Se realizaron búsquedas en PubMed utilizando términos como fibrosis retroperitoneal sola y en combinación con términos relacionados como trombosis de la vena cava inferior, trombosis venosa profunda, tamoxifeno, metotrexato. Este caso es único, ya que es muy raro encontrar trombosis venosa profunda aguda en fibrosis retroperitoneal idiopática sin desarrollo de colaterales cuando la luz de la vena cava inferior está comprometida hasta una obstrucción casi completa.Después de un seguimiento de 20 años, el paciente se encuentra bien en términos de actividad física y bienestar psicológico con antihipertensivos, tiroxina y anticoagulantes. ¿El intervalo libre de enfermedad está realmente libre de la enfermedad o simplemente disminuyó con inmunosupresores para activarse después de algún tiempo?

Protecting future antimalarials from the trap of resistance:Lessons from artemisinin-based combination therapy(ACT)failures / 药物分析学报

Having faced increased clinical treatment failures with dihydroartemisinin-piperaquine(DHA-PPQ),Cambodia swapped the first line artemisinin-based combination therapy(ACT)from DHA-PPQ to artesunate-mefloquine given that parasites resistant to piperaquine are susceptible to mefloquine.However,triple mutants have now emerged,suggesting that drug rotations may not be adequate to keep resistance at bay.There is,therefore,an urgent need for alternative treatment strategies to tackle resistance and prevent its spread.A proper understanding of all contributors to artemisinin resistance may help us identify novel strategies to keep artemisinins effective until new drugs become available for their replacement.This review highlights the role of the key players in artemisinin resistance,the current strategies to deal with it and suggests ways of protecting future antimalarial drugs from bowing to resistance as their predecessors did.

Manganese and Movement Disorders: A Review

Scientific and technological advances achieved with industrial expansion have led to an ever-increasing demand for heavy metals. This demand has, in turn, led to increased contamination of soil, water and air with these metals. Chronic exposure to metals may be detrimental not only to occupational workers but also to the nonoccupational population exposed to these metals. Manganese (Mn), a commonly used heavy metal, is an essential cofactor for many enzymatic processes that drive biological functions. However, it is also a potential source of neurotoxicity, particularly in the field of movement disorders. The typical manifestation of Mn overexposure is parkinsonism, which may be difficult to differentiate from the more common idiopathic Parkinson’s disease. In addition to environmental exposure to Mn, other potential etiologies causing hypermanganesemia include systemic health conditions, total parenteral nutrition and genetic mutations causing Mn dyshomeostasis. In this review, we critically analyze Mn and discuss its sources of exposure, pathophysiology and clinical manifestations. We have highlighted the global public health impact of Mn and emphasize that movement disorder specialists should record a detailed social and occupational history to ensure that a toxic etiology is not misdiagnosed as a neurodegenerative disease. In the absence of a definite therapeutic option, early diagnosis and timely institution of preventive measures are the keys to managing its toxic effects.

Manganese and Movement Disorders: A Review

Scientific and technological advances achieved with industrial expansion have led to an ever-increasing demand for heavy metals. This demand has, in turn, led to increased contamination of soil, water and air with these metals. Chronic exposure to metals may be detrimental not only to occupational workers but also to the nonoccupational population exposed to these metals. Manganese (Mn), a commonly used heavy metal, is an essential cofactor for many enzymatic processes that drive biological functions. However, it is also a potential source of neurotoxicity, particularly in the field of movement disorders. The typical manifestation of Mn overexposure is parkinsonism, which may be difficult to differentiate from the more common idiopathic Parkinson’s disease. In addition to environmental exposure to Mn, other potential etiologies causing hypermanganesemia include systemic health conditions, total parenteral nutrition and genetic mutations causing Mn dyshomeostasis. In this review, we critically analyze Mn and discuss its sources of exposure, pathophysiology and clinical manifestations. We have highlighted the global public health impact of Mn and emphasize that movement disorder specialists should record a detailed social and occupational history to ensure that a toxic etiology is not misdiagnosed as a neurodegenerative disease. In the absence of a definite therapeutic option, early diagnosis and timely institution of preventive measures are the keys to managing its toxic effects.

Odontogenic Keratocyst of the Posterior Maxilla: Report of an Unusual Case

ABSTRACT The odontogenic keratocyst is a developmental odontogenic cyst. It can occur anywhere in the jaws, but it is commonly seen in the posterior part of the mandible. Lesions have a propensity to grow along the internal aspect of the jaws, and clinically observable expansion of bone occurs late. These lesions have a different mechanism of growth as compared with other cysts, and may show varying radiographic appearances. This paper reports a distinctive case of an odontogenic keratocyst in a 33-year-old female patient. The cyst has an unusual radiographic presentation of two unilocular radiolucencies overlapping each other in the left maxillary premolar-molar region. The study also presents a literature review.

Intramandibular plexiform schwannoma presenting as a nonspecific benign lesion: How specific can we be? A case report with a review of the literature

Schwannoma, a benign nerve sheath tumor, is quite rare and more so in jawbones. We report a rare case of a plexiform variant of mandibular schwannoma in a 12-year-old female with a swelling in the left mandible. Clinical features were suggestive of dentigerous cyst as a result of missing premolars and canine. Occlusal and panoramic radiography revealed an osteolytic lesion with scalloping margins, bicortical plate expansion, and agenesis of several teeth. Odontogenic keratocyst, central giant cell granuloma, odontogenic myxoma, and ameloblastic fibroma were given as radiological differential diagnoses. Histopathological examination revealed features of plexiform schwannoma which was given as the final diagnosis. The lesion was treated with surgical excision. Although odontogenic cysts/tumors are often thought of in differential diagnosis whenever well-defined radiolucencies in the jaw are encountered, it is prudent to include schwannoma. This exceptional case adds light to the fact that schwannoma should not be overlooked though it is a rare possibility and must be included in differential diagnosis of odontogenic cysts/tumors

A prospective study to find the prevalence of domestic violence against married females of rural India

Background: Starting from Vedic age to twenty first century, women have never been given equal freedom as of males. It is always the women who have to be on the tight rope, subject to inequality and looked down as an inferior sex. The aim and objective of the study was to estimate the prevalence of domestic violence.Methods: 776 married females were selected by systematic random sampling from the field practice area under primary health care. Prior a pilot study was carried out among 25 married class IV female workers. A predesigned and pretested questionnaire was used and all the confidentiality was maintained. Statistical analysis was done using SPSS 21 software.Results: Average age of the respondents was 28.13 years with range 18 to 56 years. Overall 96% respondents were literate, whereas literacy rate in rural population in parent district was 67.8%. Majority number of respondents were housewives i.e. 58.37%.Conclusions: Various sociodemographic factors like age of the women, education of women and perpetrator, age at marriage of women, and the socio-economic status shows inverse relationship with occurrence of domestic violence. More economic empowerment, along with higher education, may provide women with the ground of awareness protesting platform eventually promoting protective factors against domestic violence.

A Comparative Study between Standard Weight‑Based Technique and Pinna Size-Based New Technique for Classic Laryngeal Mask Airway Size Selection in Pediatric Population

Introduction: The laryngeal mask airway (LMA) is a non-invasive supraglottic airway device designed to maintain the airway,which sits outside of and creates a seal around the larynx. In clinical practice, the most commonly used method for sizeestimation is the weight-based method. However, this may not be suitable due to lack of standardization in pediatric patients,emergencies, overweight, etc. Therefore, this study was undertaken to evaluate the efficacy of the new pinna size-basedmethod for the estimation of LMA size.Materials and Methods: A total of 100 pediatric patients, aged under 15 years, undergoing ambulatory surgeries, belonging toAmerican society of anesthesiologists (ASA) Grades I and II, were randomly divided into two groups: Weight-based and Pinnasize-based estimation. Parameters such as number of attempts and change of size required were monitored.Results: LMAs were inserted in both the groups in the first attempt. However, LMAs needed to be exchanged in 2% of casesin Group A and in 16% of cases in Group B.Conclusion: Pinna size-based estimation for the size of LMA is a convenient and feasible alternative to the traditional weightbased estimation.

A Comparative Study between the Efficacy of Pre-incisional and Post-incisional Wound Infiltration of Bupivacaine for the Relief of Post-operative Pain

Introduction: Pain, the “fifth vital sign” is an unpleasant sensation localized to a part of the body. Post-operative pain has beenwidely studied, as it causes adverse psychological and physiological effects. Many anesthetic agents and techniques have beendeveloped to minimize the post-operative pain. This study compares the effectiveness of two such techniques: Pre-incisionaland post-incisional infiltration using bupivacaine as the anesthetic agent.Materials and Methods: This prospective, randomized, non-crossover type, double-blind interventional study was conductedon 60 patients of either gender, aged 15–50 years, belonging to the American Society of Anesthesiologists Grades I and IIundergoing lower abdominal surgeries. They were randomly divided into two groups: Pre-incisional and post-incisional infiltrationgroups and were monitored for up to 24 h postoperatively for the duration of analgesia and intensity of pain.Results: The duration of post-operative analgesia was better in the pre-incisional infiltration group (540 min) compared to thepost-incisional infiltration group (360 min). Similarly, the overall mean pulse rate, mean systolic blood pressure (SBP), and meanrespiratory rate were lower in the pre-incisional infiltration group, indicating better post-operative pain relief.Conclusion: Although both pre-incisional and post-incisional infiltration of bupivacaine are safe, pre-incisional infiltrationprovides better relief of post-operative pain.

Study Of Qtc Interval In Nondiabetic Subjects With Impaired Fasting Serum Glucose And Hyperinsulinemia

INTRODUCTION: India leads the world with the largest number of diabetic subjects (nearly 40 million) and it is predicted that this number would reach almost 80 million by the year 2030. There are research works those indicate towards the genetic liability of Indians towards the insulin resistance, diabetes & obesity. The constellation of insulin resistance, impaired glucose tolerance, atherogenic dyslipidaemia, hypertension and intra-abdominal adiposity (IAA) is called metabolic syndrome. This all factors contribute to high cardiovascular risk, morbidity & mortality in population. Identification of cardiovascular risk in nondiabetic subjects at early stage might be a game changer. OBJECTIVE: The aims of our study were to evaluate the prevalence of QTc prolongation in nondiabetic subjects with impaired fasting serum glucose and hyperinsulinemia & identify the subjects with cardiovascular risks at early stage. METHOD: We estimated fasting serum glucose & insulin in multiple subjects till we found 50 nondiabetic subjects with impaired fasting serum glucose and hyperinsulinemia. For each case we matched 50 control without insulin resistance. Subjects’ heart beats were recorded on the resting ECG tracing. QTc was calculated according to Bazett’s formula. Insulin Resistance& hyperinsulinemia was defined as homeostasis model assessment of IR (HOMA-IR). RESULTS: We observed that there was significant difference in QTc interval between case & control group.CONCLUSION: This study has concluded that Insulin resistance, estimated by HOMA-IR, was strongly correlated with prolonged QTc. Prolonged QTc identifies metabolic syndrome patients with an elevated risk of cardiovascular events

Spectrum of vulvar lesions: patient’s anxiety, clinician’s concern and pathologist’s diagnostic challenge

Background: A wide variety of inflammatory, premalignant and malignant lesions can occur on the vulva. Some of the lesions are limited to the vulva, while some also involve other parts of the body. Although vulvar diseases can cause a significant issue in the patients, they are less commonly discussed than those of cervix, uterus and ovary. Most of the asymptomatic lesions remain un-noticed, and are seen during routine gynecological checkups. Common complaints in symptomatic lesions are lumps, discomfort, itching and pain. Since the symptoms are nonspecific; determining the location of the lesion can assist with the diagnosis. Being a genital part with skin covering on outer aspect and mucosal lining inside, it is associated with various dermatological, nutritional, and hormonal as well as sexually transmitted diseases. The present study thus was conducted to categorize vulvar lesions based on their histological diagnosis and also to study the morphological spectrum of precursor lesions for malignancy.Methods: Present study includes all types of vulvar lesions sent for pathological study in the Department of pathology, at GMC Nagpur over the period of one year.Results: Total 34 lesions were studied including a wide diagnostic range from inflammatory, dermatological to benign, premalignant and malignant. Inflammatory lesions including various infections and LSA (Lichen sclerosus atrophicus) were the most commonly seen lesions along with collection of neoplastic lesions.Conclusions: Proper diagnostic categorization of the lesions is essential for initiating therapy and reducing patient’s anxiety. Morphology of these lesions along with their diagnostic significance is discussed.

A mixed radiopaque – radiolucent lesion in the anterior mandible associated with multiple impacted teeth: A radiodiagnostic challenge?

Desmoplastic ameloblastoma (DA) exhibits important differences in gender, anatomic distribution, radiographic findings, and histologic appearance compared to other types of ameloblastoma. Radiologically, DA is seen either as ill-defined mass containing osteolytic and sclerotic areas or as multifocal radiodense flecks within radiolucent background resembling a honeycomb. The radiographic differential diagnosis includes fibro-osseous lesions such as cemento-ossifying fibroma, fibrous dysplasia, calcifying odontogenic cyst, and chronic sclerosing osteomyelitis. Thus, DA should primarily be included in the differential diagnosis of a mixed radiopaque-radiolucent lesion with diffuse borders in the anterior premolar region of the jaws. This report adds to the literature of mixed radiolucent-radiopaque lesions which may not always be histopathologically diagnosed as a fibro-osseous lesion but could turn out to be a DA. This report also benefits the dental community by cautioning them to be aware of DA that can be associated with multiple unerupted teeth which is quite a rare finding.

Antihypertension medication adherence and associated factors at tertiary care hospital, Gujarat, India

Background: According to world health organization (WHO) describes poor adherence as the identical cause of uncontrolled blood pressure and estimates that 50-70% of people do not take their antihypertensive medication as prescribed. The objectives of this study were to investigate the adherence and persistence of antihypertensive drugs in Indian rural population as well as monitoring adverse drug reactions and its relation to compliance.Methods: This cross-sectional study conducted among 300 hypertensive patients taking treatment at tertiary care hospital in Gujarat, India. Structured questionnaires consisting of open and closed ended questions on the antihypertensive drug adherence were distributed to patients for those found on the study area at time of data collection and the left-over pills of individual patient were counted to strengthen the consistency of the research.Results: Prevalence of non-adherence found in 24.3% participants. Present study found statistically significant association between socio-demographic factors (age, religion, marital status, occupation, substance abuse, education and family history of HT) with treatment adherence of hypertension among study participants. The other factor associated to non-adherence was therapy factor 32.9% (P=0.001) from the total non-adherence, in this case patients were supposed to unwanted effect of the drug and they were not able to take the medication.Conclusions: The main possible reasons for non-adherence were ‘refuse to take regular treatment’,‘cost of treatment’, ‘poor patient-doctor relation’, ‘unwanted side effect of drugs’ and other factors like age, marital status, occupation, education level, family H/O, substance abuse and religion are also playing supporting role to develop non-adherence to treatment

Computed Tomography Guided Fine Needle Aspiration Cytology of Lung and Mediastinal Lesions

Introduction: Computed tomography guided fine needleaspiration cytology is a safe and well established technique forthe diagnosis of lung and mediastinal lesions. This study wascarried out in the department of pathology in the tertiary healthcare and teaching institute where radiology department is wellestablished. The aim was to study the cytomorphology of thespectrum of the lung and mediastinal lesions and to correlatethe cytological diagnosis with the radiological diagnosis.Material and methods: Computed tomography guided fineneedle aspiration cytology was done in 90 pateints after takingwritten consent of the patient. Patients were explained thebenefits and risks of the procedure. The results were analysed.Results: A total of 90 patients were included in the study.There were 81 patients of lung lesions and nine patients ofmediastinal lesions. There were 63(70%) males and 27(30%)females. Adequate aspirate was obtained in 77 patientsgiving the adequacy rate of 85.55%. Adenocarcinomawas the most common type of lung malignancy and NonHodgkins Lymphoma was the most common malignancyin the mediastinum. Inflammatory lesions were seen in 13cases. Granulomatous lesions were found in six patients. Oneinteresting case of hydatid with aspergillosis was diagnosedon cytology smears, which on radiology was diagnosed asneoplastic. Pneumothorax was seen in three patients. Nopatient required chest tube insertion.Conclusion: Computed tomography guided fine needleaspiration cytology is a safe and reliable method for thediagnosis of lung and mediastinal lesions. It can help inearly diagnosis and initiation of the treatment avoiding majorsurgical procedures.

Glandular Odontogenic Cyst Of The Mandible: A Case Report And Literature Review

Glandular odontogenic cyst (GOC) is a rare developmental odontogenic cyst that has gained special attention primarily due to its aggressive potential and the microscopic features, it shares with central mucoepidermoid carcinoma of the jaws. This relatively new entity has a prevalence rate of 0.17% and lacks pathognomonic clinicoradiographic features, making the correct diagnosis a major challenge. This report describes a case of GOC presenting as a solitary osteodestructive lesion in the anterior mandible of a 54-year-old male. Cone-beam computed tomography (CBCT) images revealed a multilocular radiolucent lesion with bicortical expansion, cortical thinning, and perforation, indicating an aggressive potential. Histopathology revealed pseudoglandular epithelium with daughter cysts within the stroma, suggesting an invasive nature. The patient was diagnosed and treated in our institution. In view of the high probability of recurrence of GOC, CBCT evaluation and histopathological examination are essential. An aggressive treatment approach is recommended followed by long-term follow-up.