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Indian J Pediatr ; 2001 Jun; 68(6): 563-6
Artigo em Inglês | IMSEAR | ID: sea-81177

RESUMO

Glanzmann's thrombasthenia (GT) is an uncommon cause of bleeding in children. We diagnosed two siblings as having GT on the basis of flow cytometric studies. Both had cutaneous bleedings and epistaxis since early childhood. Hematological investigations revealed prolonged bleeding time and a normal platelet count. Both the patients had absence of aggregation of platelets with the agonist adenosine diphosphate. Absence of the GPIIb/IIIa receptor was confirmed by flow cytometry. A short review of the disorder is presented.


Assuntos
Pré-Escolar , Diagnóstico Diferencial , Feminino , Citometria de Fluxo , Transtornos Hemorrágicos/genética , Humanos , Masculino , Complexo Glicoproteico GPIIb-IIIa de Plaquetas/genética , Trombastenia/diagnóstico
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