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The Journal of the Korean Society for Transplantation ; : 59-68, 2016.
Artigo em Coreano | WPRIM | ID: wpr-45804

RESUMO

The complement system is a part of the innate immune system that potentiates the ability of antibodies and phagocytic cells to clear microbes and damaged cells. The complement system consists of a number of proteins circulating as inactive precursors. It is stimulated mainly by three pathways: the classical pathway, the alternative pathway, and the lectin pathway. There are many genetic polymorphisms in this system, which can over-activate the immune system. In this study, we collected the polymorphisms reported to over-activate complement cascades that affect the immune system and induce autoimmune diseases.


Assuntos
Anticorpos , Doenças Autoimunes , Proteínas do Sistema Complemento , Sistema Imunitário , Fagócitos , Polimorfismo Genético
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