Clinical curative efficacy of inducing remission for the newly diagnosed aged AML patients by chemotherapy with IA and DA regimens / 中国实验血液学杂志

This study was aimed to explore the clinical efficacy and toxicity of idarubicin (IA regimen) and daunoru-bicin combined with cytarabine (DA regimen) for treating aged patients with AML as induction chemotherapy. The clinical data of 60 newly diagnosed AML aged patients treated with IA or DA regimen were analyzed retrospectively. IA regimen group included 22 patients (8 male and 14 females with median age of 66 yrs), while the DA regimen group included 38 patients (20 males and 18 females with median age of 64 yrs). The complete remission rate, total effective rate and adverse effects after one chemotherapy course were compared. The results showed that the CR rate in IA regimen group was 63.63%, which was significantly higer than that in DA regimen group (31.58%) (P < 0.05). The total effective rate was 63.63% and 36.84% respectively in IA and DA regimen groups, there was significant difference between the two groups (P < 0.05). Both the hematological and non-hematological adverse effects were observed and no difference was found in the two regimen groups, neither in myelosupression (P > 0.05), the major hematological adverse effects, nor in non-hematological adverse effects (P > 0.05). It is concluded that for aged AML patients, IA regimen can achieve a higher CR rate and higher total effective rate than that in DA regimen without increase of adverse effects after one induction chemotherapy course.

Correlation between the peripapillary retinal nerve fiber layer thickness,structure changes in non - proliferative diabetic retinopathy and the changes of visual function / 国际眼科杂志(Guoji Yanke Zazhi)

AlM: To study the correlation between and the peripapillary retinal nerve fiber layer ( RNFL ) thickness, structure changes in non-proliferative diabetic retinopathy ( NPDR) and the the changes of visual function METHODS:Eighty cases ( 80 eyes ) of patients with NPDR who were in our hospital from January 2011 to December 2013 as group NPDR, 60 cases of patients ( 60 eyes) without retinopathy who were in the hospital were selected as non-diabetic retinopathy group ( NRD) group, meanwhile, 50 healthy people who had health examination in our hospital as control group. The RNFL thickness and visual electrophysiological testing were performed on the study objects in the three groups, and the results were compared among groups. RESULTS: Group NPDR's above, below, nasal, temporal and average RNFL thickness were 91. 52 ± 18. 52, 88.63±21. 65, 63. 62±11. 72, 60. 42±9. 13, 69. 36±12. 52μm, those of group NPDR were 111. 32 ± 21. 90, 113. 57 ± 22. 67, 74.31±11. 74, 67. 64±12. 34, and 97. 31±11. 43μm,those of group control were 121. 65±21. 42, 129. 32±23. 31, 82. 42±9. 28, 80. 32±8. 51, 102. 54±21. 82μm. To compare of average thickness of RNFL of three groups, groups NPDR and NPD were thinner than that of control group;To compare each quadrant phase, above, below, nasal, the RNFL thickness among three groups had statistical significance (P0. 05);At the same time, 60′P100 latency (MS), 60′P100 amplitude ( V ) , 15′ P100 latency ( MS ) and 15′ P100 amplitude ( V) of three groups had statistical significance (P CONCLUSlON: The changes of RNFL thickness have occurred in the early time of NPDR, and mainly the above, below and temporal , and it has a significant relevance with the changes of visual function.