Comparison of Pre- and Post-Operative Liver Function after Halothane and Enflurane Anesthesia / 대한마취과학회지

The problem of hepatotoxicity of clinically employed halogenated inhalation anesthetics has major implications for the practice of anesthesiology. Because of emerging disadvantages with all the available anesthetics, chemists continue to search for better compounds. In 1963 Terrel synthesized enflurane and many anesthesiologist used it, hoping to avoid the disadvantage of halothane. This study was undertaken to investigate the advantage of enflurane as compared to the disadvantege of halothane, by comparing of pre- and post- operative liver functions of 16 cases of halothane use and 16 cases of enflurane use. in this study, all cases physical status were all ASA class 1, and excluded patients who had any liver disease, jaundice, previous experience of halothane or enflurane anesthesis, and who had not been transfused during this study. The result of this study which compared pre-operative and post-operative liver function tests disclosed statistically significant change in SGOT(p<0.02). On table lll the comparison of liver function tests between halothane and enflurane disclosed significant difference and that enflurane in less hepatotoxic than halothane. Considering the allergic or the intermediate by-product theory of the mechanism of halethane hepatoxicity, it is desirable to avoid repeating the use of halothane in the near future. Thus, it seems to be safer to use enflurane instead of halothane.

Effects of Enflurane Anesthesia and Surgery on Thyroid Function / 대한마취과학회지

This study was performed to investigate the effects of enflurane anesthesia and surgery on thyroid function by determining the plasma concentration of thyroxid(T4) and trilodothyronine(T3) in 10 patients who had neither hepatic disorder nor endocrine disease. Each patient was premedicated with diazepam 10mg and atropine sulfate 0.5mg intramuscularly one hour before induction of anesthesia. Anesthesia was induced with pentohal sodium and maintained with enflurane and oxygen supplemented with pancuronium bromide in divided dose as needed. plasma concentrations of thyroxine and triiodothyronine were measured by means of radiommunoassay. The results obtained were as follows: 1) No significant change in the plasma concentration of thyroxine was detected during enflurane anesthesia and surgery. 2) Plasma concentration of triidothyronine decreased significantly, compared with the control level, during enflurane anesthesia alone and anesthesia plus surgery. Although the precise mechanisms for the decrease in triiodothyronine following anesthesia and surgery remain unknown, decreased peripheral conversion from T4 to T3 may be responsible for this decline. Our data imply that enflurane anesthesia did not stimulate thyroid funcion judged by plasma concentration of T4 or T3. Therefore, enflurane anesthesia may be an useful anesthetics for patients with hyperthyroidism.