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1.
Asian Spine Journal ; : 127-140, 2022.
Artigo em Inglês | WPRIM | ID: wpr-925590

RESUMO

Posterior lumbar fusion is a safe and effective surgical method for diseases, such as lumbar stenosis, spondylolisthesis, lumbar instability, spinal deformity, and tumor. Pedicle screw (PS) fixation was first introduced by Bouche and has been adopted as the gold standard for posterior lumbar fusion. Santoni and colleagues introduced a new methodological screw insertion technique that uses a cortical bone trajectory (CBT), described as that from a medial to lateral path in the transverse axial plane and caudal to the cephalad path in the sagittal plane through the pedicle for maximum contact of the screw with the cortical bone. Owing to the lower invasiveness, superior cortical bone contact, and reduced neurovascular injury incidence, the CBT technique has been widely used in posterior lumbar fusion; however, these advantages have not been proven in clinical/radiological and biomechanical studies. We designed the present study to review the existing evidence and evaluate the merit of CBT screw fixation. Six electronic databases were searched for relevant articles published in August 2020 using the search terms “cortical bone trajectory,” “CBT spine,” “CBT fixation,” “cortical pedicle screws,” and “cortical screws.” Studies were analyzed and divided into the following groups: “biomechanics investigation,” “surgical technique,” and “clinical/radiological studies.” Most studies compared CBT and PS fixation, and the CBT screw fixation method showed better or similar outcomes.

2.
Clinics in Orthopedic Surgery ; : 208-219, 2019.
Artigo em Inglês | WPRIM | ID: wpr-739485

RESUMO

BACKGROUND: Open reduction and internal fixation using a volar locking plate has been increasingly performed for distal radius fractures. Both conventional and minimally invasive plate osteosynthesis (MIPO) techniques are widely used to treat distal radius fractures. However, it is unclear which of the techniques yields better outcomes after surgery for distal radius fractures. The purpose of this meta-analysis was to compare the benefits of conventional and MIPO techniques for distal radius fractures in terms of clinical outcomes. METHODS: Medline, Embase, and the Cochrane Central Register of Controlled Trials electronic databases were searched for articles comparing the outcomes of the conventional and MIPO techniques and published up until July 2017. Data search, extraction, analysis, and quality assessment were performed based on the Cochrane Collaboration guidelines. Clinical outcomes were evaluated using various outcome measures. RESULTS: Four clinical studies were included in the analysis. No significant clinical differences were found between the techniques in clinical hand scoring, grip strength, and range of motion. However, patient satisfaction after surgery was significantly higher in the MIPO group than that in the conventional group (standard mean difference, −0.54; 95% confidence interval [CI], −0.79 to −0.29; I2 = 0%). Furthermore, although there were no significant differences in volar tilt and ulnar variance between the two groups, radial inclination revealed a significant difference between the two groups (radial inclination: weighted mean difference, 1.20; 95% CI, 0.25 to 2.15; I2 = 19%). CONCLUSIONS: Both conventional and MIPO techniques were effective for patients with distal radius fractures. Despite limited high quality evidence to compare osteosynthesis with a volar locking plate via the conventional and MIPO techniques, the present study showed that the MIPO technique was associated with more favorable patient satisfaction.


Assuntos
Humanos , Comportamento Cooperativo , Fixação de Fratura , Mãos , Força da Mão , Procedimentos Cirúrgicos Minimamente Invasivos , Avaliação de Resultados em Cuidados de Saúde , Satisfação do Paciente , Fraturas do Rádio , Rádio (Anatomia) , Amplitude de Movimento Articular , Resultado do Tratamento
3.
The Journal of Korean Knee Society ; : 1-11, 2019.
Artigo em Inglês | WPRIM | ID: wpr-759363

RESUMO

PURPOSE: The purposes of the present study were to review published studies that investigated arthroscopic meniscus repair to treat meniscus injury in young patients and to compare all-inside and inside-out suture techniques. METHODS: Various electronic databases were queried for published articles, and this search was updated in August 2017 for evaluating the outcomes of arthroscopic meniscus surgery in young patients. Data search, extraction, analysis, and quality assessment were performed according to the Cochrane Collaboration guidelines, and the clinical outcomes were evaluated using various outcome values in young patients according to suture techniques. RESULTS: Three randomized controlled trials and three prospective comparative studies were included in this systematic review and meta-analysis. There were no significant differences in clinical outcomes such as meniscus healing rate (risk ratio [RR], 1.11; 95% confidence interval [CI], 0.90 to 1.37; I²=39%) and perioperative complications (RR, 0.62; 95% CI, 0.23 to 1.72; I²=43%) between all-inside and inside-out techniques for meniscus repair. CONCLUSIONS: The present study shows favorable results for clinical outcomes such as meniscus healing rate and perioperative complications in young patients. Furthermore, based on our results, both all-inside and inside-out meniscal suture techniques are equally effective in these patients.


Assuntos
Humanos , Comportamento Cooperativo , Joelho , Estudos Prospectivos , Técnicas de Sutura , Suturas , Lágrimas
4.
The Journal of Korean Knee Society ; : e8-2019.
Artigo em Inglês | WPRIM | ID: wpr-917078

RESUMO

PURPOSE@#The purpose of this study is to review the use of an allograft or autograft in medial patellofemoral ligament (MPFL) reconstruction.@*MATERIALS AND METHODS@#Various electronic databases were searched for relevant articles published from January 2000 to September 2017 that evaluated clinical outcomes of MPFL reconstruction using an autograft or allograft. Data search, extraction, analysis, and quality assessments were performed based on Cochrane Collaboration guidelines.@*RESULTS@#The study of 21 autografts and one allograft was included in this review. Although direct comparative studies were unavailable, the Kujala score and subjective results were reported in the majority of these studies. While the use of an autograft for MPFL reconstruction yielded satisfactory clinical outcomes with few perioperative complications, no new outcome has been drawn from the use of allografts.@*CONCLUSIONS@#Although many studies have shown favorable clinical results for MPFL reconstruction using an autograft, the clinical results of MPFL reconstruction using an allograft have not yet been sufficient to achieve meaningful clinical results due to low levels of evidence. Direct comparisons were not conducted because there were very few studies on allografts; thus, further research in this area should be performed in the future.

5.
Clinics in Orthopedic Surgery ; : 448-454, 2018.
Artigo em Inglês | WPRIM | ID: wpr-718647

RESUMO

BACKGROUND: Traumatic spinal cord injury (SCI) is a tragic event that has a major impact on individuals and society as well as the healthcare system. The purpose of this study was to investigate the strength of association between surgical treatment timing and neurological improvement. METHODS: Fifty-six patients with neurological impairment due to traumatic SCI were included in this study. From January 2013 to June 2017, all their medical records were reviewed. Initially, to identify the factors affecting the recovery of neurological deficit after an acute SCI, we performed univariate logistic regression analyses for various variables. Then, we performed a multivariate logistic regression analysis for variables that showed a p-value of < 0.2 in the univariate analyses. The Hosmer-Lemeshow test was used to determine the goodness of fit for the multivariate logistic regression model. RESULTS: In the univariate analysis on the strength of associations between various factors and neurological improvement, the following factors had a p-value of < 0.2: surgical timing (early, < 8 hours; late, 8–24 hours; p = 0.033), completeness of SCI (complete/incomplete; p = 0.033), and smoking (p = 0.095). In the multivariate analysis, only two variables were significant: surgical timing (odds ratio [OR], 0.128; p = 0.004) and completeness of SCI (OR, 9.611; p = 0.009). CONCLUSIONS: Early surgical decompression within 8 hours after traumatic SCI appeared to improve neurological recovery. Furthermore, incomplete SCI was more closely related to favorable neurological improvement than complete SCI. Therefore, we recommend early decompression as an effective treatment for traumatic SCI.


Assuntos
Humanos , Descompressão , Descompressão Cirúrgica , Atenção à Saúde , Modelos Logísticos , Prontuários Médicos , Análise Multivariada , Fumaça , Fumar , Traumatismos da Medula Espinal , Medula Espinal , Coluna Vertebral
6.
The Journal of the Korean Orthopaedic Association ; : 319-326, 2017.
Artigo em Coreano | WPRIM | ID: wpr-655864

RESUMO

PURPOSE: The purpose of this study is to evaluate the risk factors for the occurrence of cut-out of proximal femoral nail by a lag screw as the treatment for intertrochanteric fractures. MATERIALS AND METHODS: A total of 151 patients (76 males and 75 females; mean age, 73.7±12.1 years), who were diagnosed with intertrochanteric fracture at Gyeongsang National University Hospital between January 2011 and March 2016, with a follow-up of at least for 6 months were included in this retrospective study. Various risk factors, such as demographic data, osteoporosis, collodiaphyseal angle (CDA) (≤130° or >130°), tip-apex distance (TAD) (≤25 mm or >25 mm), and the position of lag screw in the femur head (quadrant) related to the occurrence of cut-out were taken into consideration. The strength of association for each factor was determined through the calculation of the odds ratio (OR), within the 95% confidence interval (CI). First, we performed univariate logistic regression analyses for all variables; then, we performed a multivariate logistic regression analysis, using only the significant variables that had resulted from the univariate analysis. RESULTS: Among the 151 cases, the occurrence of cut-out was observed in 14 cases (9.3%). In a univariate analysis, the fracture patterns based on the AO/OTA classification (p=0.045), CDA (p<0.001) and the position of lag screw in the femur head (quadrant) (p=0.001) showed a significant association with the occurrence of the cut-out. However, TAD was not significantly associated with the cut-out (p=0.886). Various factors, which were significant in univariate analyses, were included in multivariate analyses. In multivariate analyses, CDA (OR, 12.291; 95% CI, 2.559-59.034; p=0.002), and quadrant (OR, 7.194; 95% CI, 1.712-30.303; p=0.007) were significantly associated with the cut-out. CONCLUSION: Valgus reduction and proper position of lag screw were critical for the prevention of occurrence of cut-out when treating intertrochanteric fracture using proximal femur nail.


Assuntos
Feminino , Humanos , Masculino , Classificação , Cabeça do Fêmur , Fêmur , Seguimentos , Fraturas do Quadril , Modelos Logísticos , Análise Multivariada , Razão de Chances , Osteoporose , Estudos Retrospectivos , Fatores de Risco
7.
The Journal of Korean Knee Society ; : 246-255, 2017.
Artigo em Inglês | WPRIM | ID: wpr-759298

RESUMO

PURPOSE: This meta-analysis evaluated the benefits of single-bundle (SB) and double-bundle (DB) surgical techniques for posterior cruciate ligament reconstruction (PCLR) in terms of clinical outcomes. METHODS: Five electronic databases were searched for relevant articles published until September 2016. Clinical outcomes of both techniques were evaluated using Lysholm knee function scores, Tegner activity scores, side-to-side differences, and International Knee Documentation Committee (IKDC) objective grades. The results are presented as a risk ratio (RR) for binary outcomes and a weighted mean difference (WMD) for continuous outcomes with a 95% confidence interval (CI). RESULTS: Four randomized controlled trials (RCTs) were included. There were no significant differences in the Lysholm knee function scores (WMD=1.63; 95% CI, 0.00 to 3.27; I²=0%), Tegner activity scores (WMD=0.17; 95% CI, −0.08 to 0.43; I²=20%), side-to-side differences (WMD=−0.97; 95% CI, −2.41 to 0.47; I²=78%), and IKDC objective grades (RR=1.18; 95% CI, 1.00 to 1.39; I²=0%) at the final follow-up. CONCLUSIONS: The present study demonstrates that both SB and DB techniques for PCLR are comparable in terms of restoration of knee stability and improvement of knee function. However, it is still unclear which technique yields better clinical outcomes. To verify and further corroborate our results, more larger-scale, high-quality RCTs are encouraged.


Assuntos
Artroscopia , Seguimentos , Joelho , Razão de Chances , Ligamento Cruzado Posterior
8.
The Journal of Korean Knee Society ; : 155-164, 2017.
Artigo em Inglês | WPRIM | ID: wpr-759285

RESUMO

PURPOSE: The prevalence of periprosthetic joint infection (PJI) has increased with the increasing incidence of arthroplasty surgery. Considering identification of causative microorganisms is crucial for treatment of PJI, culture-negative (CN) PJI is a significant clinical issue. The purpose of the present study is to describe epidemiology, diagnosis and treatment of CN PJI based on review of the literature to help prevent delayed diagnosis and improve clinical outcomes of CN PJI. METHODS: MEDLINE, EMBASE, Cochrane Library and Scopus databases were searched for articles on CN PJI. Only clinical studies written in English were included. Basic science studies, letters to the editor, case reports and review articles on PJI were excluded. RESULTS: Seven studies were included in this study. The prevalence of CN PJI ranged from 0% to 42.1%. The major risk factors for CN PJI were prior antibiotic use and presence of postoperative wound drainage. Vancomycin and cephalosporins were the most commonly used antibiotics for CN PJI. Two-stage revision arthroplasty followed by 6 weeks of antibiotic therapy produced the most successful treatment outcomes. CONCLUSIONS: In most clinical studies on CN PJI, a definite diagnostic method for identifying causative microorganisms or optimal treatment strategy for CN PJI were not clearly described. Therefore, further studies are needed to establish standard diagnostic methods for identifying infecting organisms and treatment strategies for CN PJI.


Assuntos
Antibacterianos , Artroplastia , Cefalosporinas , Diagnóstico Tardio , Diagnóstico , Drenagem , Epidemiologia , Incidência , Articulações , Métodos , Prevalência , Fatores de Risco , Vancomicina , Ferimentos e Lesões
9.
Journal of Korean Society of Spine Surgery ; : 49-54, 2017.
Artigo em Coreano | WPRIM | ID: wpr-162080

RESUMO

STUDY DESIGN: Case report. OBJECTIVES: To present a rare case of a spinal epidural lymphoma mimicking a hematoma. SUMMARY OF LITERATURE REVIEW: The incidence of extranodal invasion of lymphoma is very low, and spinal compression as a clinical symptom rarely occurs in extranodal lymphoma. MATERIALS AND METHODS: A 37-year-old woman who complained of neck pain that had lasted for the past 3 months with no underlying disease visited the hospital and was treated conservatively with medication and physical therapy. Even though the patient was given an epidural injection 1 month prior to visiting our hospital, the pain lingered and the cervical myelopathy became aggravated, so the patient was initially diagnosed with epidural hematoma. This predisposed the patient to treatment strategies such as laminectomy and fusion, but the patient was ultimately diagnosed with non-Hodgkin lymphoma. RESULTS: The patient underwent a laminectomy with excision of the lesion and fusion. The patient was diagnosed with non-Hodgkin lymphoma as a result of this, and the patient's radicular pain and numbness improved immediately following surgery, except for mild weakness in both hands. CONCLUSIONS: Although spinal epidural lymphoma is similar to hematoma, and is a very rare disease, surgeons should take it into consideration in the differential diagnosis of patients with a spinal epidural lesion.


Assuntos
Adulto , Feminino , Humanos , Diagnóstico Diferencial , Mãos , Hematoma , Hipestesia , Incidência , Injeções Epidurais , Laminectomia , Linfoma , Linfoma não Hodgkin , Cervicalgia , Doenças Raras , Doenças da Medula Espinal , Cirurgiões
10.
Journal of Korean Society of Spine Surgery ; : 129-137, 2017.
Artigo em Coreano | WPRIM | ID: wpr-20787

RESUMO

STUDY DESIGN: A review of the literature regarding nucleoplasty. OBJECTIVES: This aim of this article is to provide current information on nucleoplasty as a therapeutic intervention for herniated disc or discogenic back pain in degenerative disc disease. SUMMARY OF LITERATURE REVIEW: Nucleoplasty as a therapeutic intervention for discogenic pain is performed with increasing frequency, and has been reported to involve few complications and to have satisfactory clinical results. MATERIALS AND METHODS: Review of the literature. RESULTS: In nucleoplasty, the intervertebral disc is approached percutaneously. In this paradigm, a bipolar high frequency device in combination with ablation and coagulation is used to create a channel in the intervertebral disc in order to reduce intervertebral disc volume and to decrease intervertebral pressure and inflammatory markers. Standard indications for nucleoplasty have not been established, but it has been reported that the procedure had excellent outcomes regardless of the presence of radiculopathy or the results of discography. Many studies have reported their outcomes using various categories, because the procedure is comparatively new. Concomitantly, long-term follow-up studies remain to be performed, and each study reported a different follow-up period. CONCLUSIONS: Nucleoplasty has been found to show an excellent prognosis for discogenic back pain and a low incidence of complications. Moreover, since it is a minimally invasive procedure, it offers improved possibilities for return to daily life and work. If degenerative changes have not progressed to a great extent or the intervertebral level remains intact, nucleoplasty may be considered prior to surgery. Due to the lack of reports on the subject, prospective analyses in the future are required.


Assuntos
Dor nas Costas , Descompressão , Seguimentos , Incidência , Disco Intervertebral , Deslocamento do Disco Intervertebral , Plasma , Prognóstico , Estudos Prospectivos , Radiculopatia
11.
Journal of Korean Society of Spine Surgery ; : 100-107, 2016.
Artigo em Coreano | WPRIM | ID: wpr-219357

RESUMO

STUDY DESIGN: Retrospective study. OBJECTIVES: The purpose of this study was to evaluate risk factors for subsidence after posterior lumbar interbody fusion (PLIF). SUMMARY OF LITERATURE REVIEW: Body mass index (BMI), bone mineral density (BMD), cage characteristics (titanium or poly-ether-ether-ketone (PEEK)) and degree of disc distraction are risk factors for cage subsidence after PLIF. MATERIALS AND METHODS: From January 2010 to January 2015, a total of 69 patients (93 segments) who were diagnosed with degenerative lumbar spine disease at the current authors' institution and underwent follow-up for at least 1 year were included in this retrospective study. Data on all factors related to cage subsidence were taken into consideration. The degree of association for each of the factors was determined through the calculation of odds ratios (ORs) with a 95% confidence interval. Logistic regression analyses were performed. The P-value that represented statistical significance was set below 0.05. RESULTS: There were no significant associations between fused segment level and cage subsidence (p=0.588), nor were there any significant associations between the kind of cage (titanium or PEEK) and cage subsidence (p=0.371). Using logistic regression, the factors with a P-value below the 0.20 level in univariate analyses were included in the multivariate analyses. In multivariate analyses, diabetes mellitus (DM) (p=0.029, OR, 4.524), osteoporosis (p=0.026, OR, 6.046), and degree of disc distraction (p=0.010, OR, 1.446) had significant associations with cage subsidence. In addition, there were significant associations between cage subsidence and instrument failure (p=0.008, OR, 8.235). CONCLUSIONS: DM and osteoporosis, which may affect bony structures, have significant associations with cage subsidence after PLIF. Cage insertion with excessive disc distraction during surgery may also affect cage subsidence after PLIF.


Assuntos
Humanos , Índice de Massa Corporal , Densidade Óssea , Diabetes Mellitus , Seguimentos , Modelos Logísticos , Análise Multivariada , Razão de Chances , Osteoporose , Estudos Retrospectivos , Fatores de Risco , Coluna Vertebral
12.
The Journal of the Korean Orthopaedic Association ; : 199-206, 2016.
Artigo em Coreano | WPRIM | ID: wpr-654024

RESUMO

PURPOSE: The purpose of this study is to determine the relationship between the repetitive flexion or extension posture on the cervical spine on labor and degenerative change of the cervical spine, and the factors affecting degenerative change of the cervical spine. MATERIALS AND METHODS: To determine the factors affecting degenerative change of the cervical spine, age, sex, height, weight, body mass index, smoking, diabetes mellitus (DM), time engaging in labor, and cervical spine posture (flexion or extension) required repetitively on labor were investigated in the subjects. In addition, to evaluate the level of degenerative change of the cervical spine on 83 people in the flexion group (flexion strain) and 83 people in the extension group (extension strain), cervical degenerative index (CDI) in the simple cervical spine lateral radiograph was used to score (0-60 points) the degenerative severity. RESULTS: A total of 166 subjects (flexion group: 83 people, extension group: 83 people) participated in this study, and for the CDI, the cervical spine flexion group scored 7.8±6.2 points, and the cervical spine extension group scored 12.2±6.0 points to show that the cervical spine extension group had significant degenerative change in the cervical spine. In the multiple linear regression test performed to verify the risk factors affecting the degenerative change of the cervical spine, age (p=0.004), contraction of DM (p=0.029), and extension posture of cervical spine (p<0.001) influenced the degenerative change of the cervical spine. CONCLUSION: Repetitive extension posture on the cervical spine on labor and contraction of diabetes affected degenerative change of the cervical spine, therefore, training in medical care and posture on labor are required to prevent the progression of degenerative change in the cervical spine.


Assuntos
Feminino , Agricultura , Peso Corporal , Vértebras Cervicais , Diabetes Mellitus , Modelos Lineares , Pescoço , Postura , Fatores de Risco , Fumaça , Fumar , Coluna Vertebral , Espondilose
13.
The Journal of the Korean Orthopaedic Association ; : 299-306, 2015.
Artigo em Coreano | WPRIM | ID: wpr-651466

RESUMO

PURPOSE: The purpose of this study is to evaluate risk factors for wrist stiffness after treatment of distal radius fractures. MATERIALS AND METHODS: A total of 55 consecutive patients who were diagnosed with distal radius fracture at the current authors' institution and followed-up for at least 6 months were included in this retrospective study. Data on all factors related to wrist stiffness were considered. The degree of association for each of the factors was determined by calculation of the odds ratio (OR), with a 95% confidence interval. Logistic regression analyses were performed. p-value was set below 0.05. RESULTS: Among radiologic indexes reflecting the degrees of fracture reduction, only ulnar variance showed significant association with wrist stiffness of distal radius fracture (p<0.05). In univariate analysis, age (p=0.037; OR, 1.051) and diabetes mellitus (DM) (p=0.016; OR, 8.000) showed significant association with wrist stiffness. Various factors significant at the p-value less than 0.20 level in univariate analyses were included in the multivariate analyses. In multivariate analyses, only DM (p=0.034; OR, 6.588) showed significant association with wrist stiffness. CONCLUSION: Contraction of DM is critical to avoid wrist stiffness of distal radius fracture patients. In addition, ulnar variance was considered a significant factor of wrist stiffness in distal radius fracture patients, thus reduction of fracture could be done more in proximity to normal anatomy.


Assuntos
Humanos , Diabetes Mellitus , Modelos Logísticos , Análise Multivariada , Razão de Chances , Fraturas do Rádio , Rádio (Anatomia) , Estudos Retrospectivos , Fatores de Risco , Punho
14.
The Journal of Korean Knee Society ; : 82-89, 2015.
Artigo em Inglês | WPRIM | ID: wpr-759174

RESUMO

PURPOSE: This retrospective review was conducted to identify prognostic factors for two-stage reimplantation for infected total knee arthroplasty (TKA) and the rate of reinfection following revision TKA. MATERIALS AND METHODS: Out of 88 patients diagnosed with post-TKA infection between 1998 and 2011, 76 underwent two-stage reimplantation and were reviewed in this study. The 76 patients were divided into two groups-those who experienced reinfection and those who did not. Comorbidities, culture results, and inflammation indices were analyzed and compared between the two groups. RESULTS: Of the 76 patients who underwent a two-stage reimplantation, 18 (23.7%) experienced reinfection. Patients with more than three comorbidities had significantly higher reinfection rates than those with less than three comorbidities (47.1% vs. 4.8%, p=0.032). The reinfection rate between the culture positive prosthetic joint infection group and the culture negative prosthetic joint infection group was not significantly different (p=0.056). Inflammation indices (erythrocyte sedimentation rate [ESR] and C-reactive protein [CRP]) showed a statistically significant difference between patients with reinfection and those without reinfection at 4 weeks after the first-stage surgery. CONCLUSIONS: Reimplantation must be carefully performed when the risk of reinfection is high, particularly in patients with more than three systemic or local comorbidities and higher inflammation indices (ESR and CRP) prior to revision TKA.


Assuntos
Humanos , Artroplastia , Proteína C-Reativa , Comorbidade , Inflamação , Articulações , Joelho , Reimplante , Estudos Retrospectivos
15.
Journal of the Korean Society for Surgery of the Hand ; : 198-203, 2015.
Artigo em Inglês | WPRIM | ID: wpr-118132

RESUMO

Acute ruptures of flexor tendons in patients with distal radius fractures are very rare complications. The majority of reported cases, flexor tendon rupture associated with distal radius fracture, is chronic flexor tendon ruptures, which are caused by implants for fixation or rough surfaces of malunited distal radius. We experienced an unusual case of an acute rupture of the flexor digitorum profundus tendon in a patient with a distal radius fracture, in addition to providing an auxiliary review of the literature.


Assuntos
Humanos , Fraturas do Rádio , Rádio (Anatomia) , Ruptura , Tendões
16.
Biomolecules & Therapeutics ; : 442-448, 2015.
Artigo em Inglês | WPRIM | ID: wpr-86474

RESUMO

We evaluated the chondroprotective effects of wogonin by investigating its effects on the gene expression and production of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as on production of MMP-3 in the rat knee. Rabbit articular chondrocytes were cultured in a monolayer, and RT-PCR was used to measure interleukin-1beta (IL-1beta)-induced expression of MMP-3, MMP-1, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), and type II collagen. In rabbit articular chondrocytes, the effects of wogonin on IL-1beta-induced production and proteolytic activity of MMP-3 were investigated using western blot analysis and casein zymography, respectively. The effect of wogonin on MMP-3 protein production was also examined in vivo. In rabbit articular chondrocytes, wogonin inhibited the expression of MMP-3, MMP-1, MMP-13, and ADAMTS-4, but increased expression of type II collagen. Furthermore, wogonin inhibited the production and proteolytic activity of MMP-3 in vitro, and inhibited production of MMP-3 protein in vivo. These results suggest that wogonin can regulate the gene expression and production of MMP-3, by directly acting on articular chondrocytes.


Assuntos
Animais , Ratos , Western Blotting , Caseínas , Condrócitos , Colágeno Tipo II , Expressão Gênica , Interleucina-1beta , Joelho , Modelos Teóricos , Osteoartrite , Trombospondinas
17.
Journal of the Korean Society for Surgery of the Hand ; : 142-147, 2015.
Artigo em Coreano | WPRIM | ID: wpr-22241

RESUMO

Indicators for local steroid injection on the hands include trigger finger, De Quervain's disease, carpal tunnel syndrome and trapeziometacarpal joint arthritis. Local steroid injection is an effective technique for rapid alleviation of symptoms and return to daily life. Complications following local steroid injection include depigmentation of the skin, subcutaneous fat atrophy, infection and tendon rupture. Tendon rupture and infection rarely occur as severe complications, and local steroid injection should not be abused or misused. The authors experienced a rupture of the extensor mechanism at extensor zone V after repeated local steroid injection to treat vague pain in the second metacarpophalangeal joint, followed by reconstruction of the extensor mechanism through tendon transfer and sagittal band reconstruction. We herein report a case with the literature review.


Assuntos
Artrite , Atrofia , Síndrome do Túnel Carpal , Doença de De Quervain , Dedos , Mãos , Articulações , Articulação Metacarpofalângica , Ruptura , Pele , Esteroides , Gordura Subcutânea , Transferência Tendinosa , Tendões
18.
The Journal of Korean Knee Society ; : 191-198, 2014.
Artigo em Inglês | WPRIM | ID: wpr-759156

RESUMO

Recently, several new techniques for anatomic posterior cruciate ligament reconstruction (PCLR) have emerged and are believed to restore the normal anatomy of the posterior cruciate ligament more accurately. Despite the latest trend, the optimal methods for anatomic PCLR remain controversial. The purpose of this research is to review surgical techniques for PCLR in cadaver studies and suggest consistent and reproducible technical criteria. For the review of the literature, MEDLINE and EMBASE were screened for articles on anatomic PCLR. Only basic science studies on PCLR performed on human cadavers and written in English were included. Seventeen studies were included in this systematic review. Only the tunnel positions, graft types, and surgical techniques were reported in the majority of the studies. There were many variations of the reported tunnel positions, graft types, and surgical techniques among the studies. In most studies, surgical techniques for consistent and reproducible anatomic PCLR were not explained clearly. Therefore, high level medical research should be encouraged in order to establish standard surgical techniques for anatomic PCLR.


Assuntos
Humanos , Cadáver , Ligamento Cruzado Posterior , Transplantes
19.
The Korean Journal of Sports Medicine ; : 85-91, 2014.
Artigo em Coreano | WPRIM | ID: wpr-199645

RESUMO

The purpose of this study is to evaluate the risk factors regarding the injuries from sports climbing through an epidemiologic study. We performed a questionnaire survey on sports climbers who participated in the 93th Annual Sports Festival in Daegu, in October 2012. Sixty-nine climbers (male: 57, female: 12) responded to the survey. The t-test was used for comparisons of the incidence of injury, according to sex and career. The multiple linear regression analysis and the logistic regression analysis were used for the evaluation of risk factors that affected the occurrence of injury. Overall, 58 (84.06%) climbers had history of injury. The incidences of climbing related injuries were higher than the incidences of cross-training related injuries. However, there were no significant difference (p=0.680). Also, there was no significant difference between males and females (p=0.467), and professionals and amateurs (p=0.076). Fifty (72.46%) out of 69 climbers had history of traumatic injuries, and 40 (57.97%) climbers had history of overuse injuries. Significant risk factors for traumatic injuries are leading (odds ratio, OR=17.854), speed (OR=45.246), and bouldering (OR=13.595). Significant risk factors for overuse injuries are leading (OR=23.252) and bouldering (OR=41.260). Significant risk factors for middle phalanx injuries, which happens most frequently in climbing related injuries, are leading (OR=20.625) and bouldering (OR=25.756). For traumatic injuries, leading, speed, and bouldering are prone to cause injuries, and leading and bouldering are significant factors for overuse injuries. Therefore, it is considered that the systematic organized training can help reduce the incidence of injury.


Assuntos
Feminino , Humanos , Masculino , Atletas , Traumatismos em Atletas , Transtornos Traumáticos Cumulativos , Estudos Epidemiológicos , Férias e Feriados , Incidência , Modelos Lineares , Modelos Logísticos , Inquéritos e Questionários , Fatores de Risco , Esportes
20.
Journal of Korean Foot and Ankle Society ; : 329-333, 2013.
Artigo em Coreano | WPRIM | ID: wpr-195907

RESUMO

Controversies exist regarding the treatment options for the end-stage arthritic change in the lateral tarsometatarsal joints. Arthrodesis has been frequently performed, but has a disadvantage of sacrificing a mobile joint. Resection arthroplasty also gained its popularity, especially in the patients with Rheumatoid arthritis, but possible hypermobility can lead to deformity. We report a successful clinical outcome of a patient with Rheumatoid arthritis in the 4th, 5th tarsometatarsal joints treated with tendon interpositional arthroplasties.


Assuntos
Humanos , Artrite Reumatoide , Artrodese , Artroplastia , Anormalidades Congênitas , Articulações , Tendões
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