Effect of chronoexercise on circadian expression of clock genes / 南方医科大学学报

<p><b>OBJECTIVE</b>To investigate the molecular biological mechanism of chronoexercise regulating circadian.</p><p><b>METHODS</b>Expressions of mPer1 and mPer2 in the diencephalon of golden hamster were determined 2 hours after acute exhaustive exercise (circadian time 6) by quantitative RT-PCR.</p><p><b>RESULTS</b>Chronoexercise at CT6 significantly decreased expressions of mPer1 and mPer2 in the diencephalon of golden hamster.</p><p><b>CONCLUSION</b>Inhibitory effect of chronoexercise on Per1 and Per2 mRNA levels in the diencephalon of golden hamster at CT6 may be achieved transcription-translation-based autoregulatory negative feedback loop.</p>