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Objective To investigate the effect of resveratrol on levels of serum interleukin family of acute hemorrhagic shock patients and study its protective effect for secondary heart and lungs injury.Methods 42 cases of acute hemorrhagic shock were collected and divided into experimental group and control group according to different drugs treatment, each group had 21 cases.Control group were given continuous low flow oxygen, fluid infusion and other basic treatment, given blood transfusion if necessary.On the basis of control group, experimental group was given resveratrol 30 mg/kg, orally, one time per day for 4 consecutive weeks.The life index were detected during the treatment period.Then the levels of serum CK, LDH, IL-6, IL-10, IL-12, LVP, +dp/dtmax ,-dp /dtmax and arterial blood gas of all patients were detected after treatment.ResuIts Compared with control group, the levels of CK and LDH in experimental group decreased significantly (P<0.05);IL-6, IL-10, IL-12 levels decreased significantly (P<0.05).LVP,+dp /dtmax , -dp /dtmax level increased significantly ( P<0.05 ); PaCO2 and pH levels decreased significantly, the level of PaO2 increased significantly (P<0.05).ConcIusion Resveratrol can significantly reduce the serum IL-6, IL-10, IL-12l, reduce the CK, LDH level of hemorrhagic shock patients, and alleviate the injury of heart and lung.
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Objective To clarify the differential diagnosis between limb-girdle muscular dystrophy type 2B (LGMD2B) and polymyositis (PM). Methods Analyzed the character of clinical, histochemical and immunohistochemical pathologic with biopsied skeletal muscle in 5 patients with LGMD2B and the relationship with PM. Results Both LGMD2B and PM showed the muscle weakness in proximal limbs and elevated creatinkinase level and electromyogram showed myogenic damage. Histochemical stains: it was similar to PM, that was the muscle fibers degenerating, regenerating and necrotic and the infiltrating inflammatory cells in different extent in 5 patients. Immunohistoehemical stains: anfi-Dysferlin monoelonal antibody showed that Dysferlin was deficient on sarcolemma in LGMD2B, but it was normal in PM. Conclusions It is resemble on the clinical and histoehemieal pathologic characters in both LGMD2B and PM. It is key to antidiastole LGMD2B and PM by the immunohistochemieal stain of anti-Dysferlin monoelonal antibody.
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Objective To investigate the clinical and pathological features of limb-girdle muscular dystrophy type 2B(LGMD2B).Methods The clinical data and the pathological result of skeletal muscle in five patients with LGMD2B were analyzed retrospectively.Results Five patients presented muscle atrophy and weakness(four limbs in three patients and both lower limbs in two patients),and the chronic onset,and the progressive deterioration.The pathological examination showed that the muscle fibers degenerating,necrotic and regenerating in different extents were observed,and the infiltration of inflammatory cells were appeared on all of cases.Immunohistochemical stains showed that the expression of anti-dysferlin monoclonal antibody was negative,anti-Dystrophy,Sarcoglycan and dystroglycan monoclonal antibodies were positive normaly,anti-CD8+T cell monoclonal antibody was negative,and anti-MHC-1 monoclonal antibody was up-regulated in five patients.Conclusions The clinical characters of LGMD2B are chronic onset,progressive muscle atrophy and weakness in four limbs or both lower limbs.The pathological characters of LGMD2B are similar to the changes of polymyositis.