RESUMO
Objective: To investigate the value of whole tumor texture features derived from ADC mapping in distinguishing high grade glioma (HGG) from low grade glioma (LGG) of brain. Methods: Totally 66 patients with pathologic proven brain glioma were enrolled, including 41 HGGs and 25 LGGs. Then 107 texture features were derived from whole tumor ADC mapping. The texture features and clinical characteristics were compared, and the variates with statistical significance at univariate analysis were entered into Logistic analysis to find out the independent risk factors for HGG. ROC curves were constructed to determine the diagnostic performance of HGG. Results: The univariate analysis revealed that the gender and age of patients as well as 3 texture features were different between HGGs and LGGs. Logistic analysis showed that age (P=0.002, OR=1.090) and ZoneEntropy (P=0.003, OR=2.984) were independent risk factors for HGG. Combining age and ZoneEntropy, the AUC of identifying HGG was 0.844, with a sensitivity of 75.6% and a specificity of 88.0%. Conclusion: The whole tumor ADC-derived texture features are useful for grading of brain glioma grade. Combining texture features with clinical characteristics can obtain high diagnostic performance.
RESUMO
The mutation of isocitrate dehydrogenase (IDH) gene is associated with gliomagenesis.It has also significant positive effects on survival and chemosensitivity in comparison with IDH wild-type glioma.Being an important energetic metabolism enzyme,mutation of IDH results in changes of microstructures and metabolism.Quantitative multimodality MR imaging has ability to obtain imaging biomarkers about microstructural,physiologic and functional information,which demonstrates the promises to assess IDH gene status in vivo.The progresses of association between quantitative multimodality MRI features and IDH genesmutations in glioma were reviewed in this paper.
RESUMO
The mutation of isocitrate dehydrogenase (IDH) gene is associated with gliomagenesis.It has also significant positive effects on survival and chemosensitivity in comparison with IDH wild-type glioma.Being an important energetic metabolism enzyme,mutation of IDH results in changes of microstructures and metabolism.Quantitative multimodality MR imaging has ability to obtain imaging biomarkers about microstructural,physiologic and functional information,which demonstrates the promises to assess IDH gene status in vivo.The progresses of association between quantitative multimodality MRI features and IDH genesmutations in glioma were reviewed in this paper.