RESUMO
Objective:To investigate the efficacy and safety of plasma exchange (PE) combined with plasma perfusion (PP) in treatment of liver failure and the influence on inflammatory factors and liver function.Methods:98 patients with liver failure in our hospital from February 2014 to February 2016 were selected as the subjectswere,and they were randomly divided into experimental group and control group,and each group was 49 cases.The experimental group was treated with PE combined with PP,and the control group was received PE alone.The liver function before and after treatment was detected by automatic biochemical analyzer.The serum levels of C-reactive protein (CRP),tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined by enzyme-linked immunosorbent assay (ELISA).The total effective rate,the incidence of side effects,the levels of liver function and inflammatory factors before and after treatment were compared between the two groups.Results:The clinical effective rate in the experimental group (91.84％) was significantly higher than that in the control group (73.47％),the difference was statistically significant (P＜0.05).The incidence of adverse reactions in the experimental group (10.20％) was significantly lower than that in the control group (38.78％),the difference was statistically significant (P＜0.05).The levels of serum alanine aminotransferase (ALT),total bilirubin (TBIL) and blood ammonia (NH3) were significantly decreased in both groups after treatment (all P＜0.05).Albumin (ALB) and thrombin activity (PTA) were significantly increased in both groups after treatment (both P＜0.05).After treatment,the serum levels of ALT,TBIL and NH3 in the experimental group were lower than those in the control group (all P＜0.05),the levels of ALB and PTA were higher than those of the control group,the difference was statistically significant (both P＜0.05).After treatment,the serum levels ofCRP,TNF-α and IL-6 were lower than those before treatment,and the serum levels of CRP,TNF-α and IL-6 in the experimental group were lower than those in the control group (all P＜0.05).Conclusion:The combination of plasma exchange and plasma perfusion has a good effect in the treatment of liver failure,and the incidence of adverse reactions is low.It can effectively remove inflammatory factors,improve liver function and improve the quality of life of patients.
RESUMO
Objective To investigate and compare the therapeutic effect of aripiprazole and risperidone in the treatment of psychiatric symptoms in Alzheimer’s disease dementia. Methods 64 patients of Alzheimer's disease dementia with psychiatric symptoms,were divided into risperidone donepezil group (A) and aripiprazole donepezil group (B ) . Before and 4, 8 weeks after treatment, the BEHAV-AD scale was used to assess the pathological behavior and the side effects scale (TESS) was used to assess adverse drug reactions.Results A group at 4 weeks after treatment BEHAV-AD score showed no significant difference with before treatment ( >0.05), 8 weeks after treatment decreased significantly (0.05) . 4 weeks after treatment,the two groups had no significant difference in TESS score ( >0.05), 8 weeks after treatment the TESS scores in group B were significantly lower in group A ( <0.05) .Conclusion Aripiprazole + donepezil can effectively alleviate the symptoms of these patients with lower mental side effects, and has better effect in treatment of Alzheimer's disease dementia with psychiatric symptoms.