RESUMO
Objective To explore the clinical and imaging characteristics of synovitis,acne,pustulosis,hyperostosis,osteitis(SAPHO syndrome),to improve the recognition of this disease.Methods Clinical and imaging data were respectively analyzed in 12 SAPHO patients with the review of literature.Results In the 1 2 SAPHO cases,9 were females and 3 were males,with an average age of (45 ±6)years.All the 1 2 cases had bone changes on the anterior-superior chest wall,which manifested as osteosclerosis,hyperplasia and joint destruction.There were 5 cases manifested as symmetrical lesion which were the typical sea gull sign or cow head sign with the proportion of 41.7%.There were 4 cases with the lesion involving the spine including 3 cases in the thoracic vertebra and 1 case in the lumbar vertebra,which showed the erosion and sclerosis in the endplates and destruction of the anterior and posterior vertebral angles.There were 2 cases with the lesion involving the sacroiliac joints,including 1 unilateral and 1 bilateral case,which showed as joint destruction.In the 12 cases,there were 11 cases with obvious cutaneous pathological changes,including palmoplantar pustulosis in 8 cases and acne in 3 cases.Conclusion SAPHO syndrome can be diagnosed by combining skin lesions and bone changes on the patient’s anterior-superior chest wall.