RESUMO
Background: The effective dose of Tranexamic Acid (TA) is unclear in reducing blood loss after cardiac surgery. In Vietnam, the doses of TA 10mg/kg for starting anaesthesia, 5mg/kg for transfusion into extracorporeal circulation solution, then using a maintained dose of 1mg/kg/gi\u1edd reduces blood loss and transfusion, but there is no statistical significant. Objectives: To evaluate blood loss and need for transfusion after cardiac surgery in patients receiving TA 20 mg/kg at induction + 10 mg/kg in extracorporeal circulation solution and 2 mg/kg/1h for maintenance; To evaluate coagulation profile after TA. Subject and methods: A double blind randomly controlled trial is conducted in 80 surgical cardiac patients equally divided into TA and control groups: Results: In the TA group, the post - operative blood loss is 393.50 \xb1 136.64 ml, Hematocrit (Hct) 35.31 \xb1 3.38 % with less individuals and smaller amount of blood and/or frozen fresh platelets needed than in control (p<0.001). Conclusions: An above dose of TA reduces approximately a half of blood loss and elevates Hct postoperatively, with significant lower requirements of transfusion than the control and higher amount of platelets, reduced D-dimers (p<0.05) and unchanged Fibrinogen, PT, INR and aPTT (p >0.05).
Assuntos
Ácido TranexâmicoRESUMO
Background: Diseases due to parasites transmitted through food, including liver fluke and intestinal fluke a dangerous disease groups for people.\r\n', u'Objectives: to evaluate trematode infection situation in epidemic areas before providing drug to treat massively high-risk subjects.\r\n', u'Subjects and methods: A cross-sectional study was carried out in two communes of Nghia Hung district, Nam Dinh province to determine the trematode infection in human in August 2007. Families were randomly selected, and all of members of households were examined for trematode eggs by Kato-Katz technique. A total of 578 people, comprising 321 males (55.5%) and 257 females (44.5%) underwent stool examination. T\r\n', u'Results:120 (37.4%) males and 66 (25.7%) females were positive for small trematode eggs. There was a significant difference between males and females for infection rates with small trematode (X2 = 8.43; p < 0.05). The infection rate of trematodes was lowest in \u2264 20 age group and highest in >60 years old among both males and females. In the majority of the patients with small trematode eggs, the infection intensity was low: about 90.3% whereas 9.7% had moderate infection intensity. High intensity rate (>10.000 epg) was not found. \r\n', u'Conclusion: Trematode infection situation through food is still a healthy problem at investigated epidemic areas. \r\n', u'