RESUMO
Objective: to analyse the effects of combined acupuncture anesthesia on surgical dosage and serum interleukin-4 [IL-4], interleukin-10 [IL-10] of pneumonectomy patients
Study Design: a randomised controlled trial [RCT]
Place and Duration of Study: lanzhou University Second Hospital, Lanzhou, China, from January 2016 to November 2017
Methodology: a total of 110 patients undergoing pneumonectomy were randomly divided into group A and group B, with 55 cases in each group. Group A was treated with combined 2Hz acupuncture anesthesia, while group B was treated with combined 2Hz/100Hz acupuncture anesthesia. The additional propofol, fentanyl dosage, and changes in heart rate and systolic blood pressure 5 min before and during extubation were compared between the two groups. The serum IL-4 and IL-10 levels were measured 10 minutes after skin incision and 24 hours after surgery using ELISA. Pain was rated by visual analogue scale [VAS] at 24 hours after surgery
Results: there was no statistically significant difference between group A and group B in the intraoperative additional propofol and fentanyl dosages [p=0.541 and 0.719, respectively]. There is no statistical difference in heart rate and systolic blood pressure between group A and group B at 5 minutes before and during extubation [p=0.151, 0.660 and 0.734, 0.528, respectively]. There is no statistical difference between group A and group B in serum IL-4 and IL-10 levels 10 minutes after surgical incision [p=0.916 and 0.841, respectively]. However, serum IL-4 and IL-2 levels in group A are statistically lower than that of group B at 24 hours after surgery [all p<0.001]. The VAS score at 24 hours after surgery in group A was 2.44 +/- 0.71 points, which was significantly lower than that of group B [3.82 +/- 0.77 points, p<0.001]
Conclusion: combined 2 Hz, 2 Hz/100 Hz acupuncture anesthesia need few anesthetic dosages of propofol and fentanyl to stabilise the patient's blood pressure and heart rate when intubated under general anesthesia; but combined 2 Hz acupuncture anesthesia can reduce IL-4 and IL-10 levels during surgery stress to a greater extent than the latter, and can effectively lower patients' serum IL-4, IL-10 expression after surgery