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Braz. J. Pharm. Sci. (Online) ; 58: e191026, 2022. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1384003

RESUMO

In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 µg/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity


Assuntos
Piridinas/análise , Tiazóis/análise , Triazóis/análise , Métodos , Antioxidantes , Técnicas In Vitro/métodos , Bactérias Gram-Positivas/classificação
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