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1.
Artigo em Inglês | IMSEAR | ID: sea-21077

RESUMO

Administration of carbon tetrachloride to normal rats increased activities of hepatic 5(1)-nucleotidase, acid phosphatase, acid ribonuclease while the activities of succinate dehydrogenase, glucose 6-phosphatase, superoxide dismutase and cytochrome P450 were decreased. Levels of lipid peroxides, total lipids and cholesterol of liver were also increased. The activities of serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and alkaline phosphatase were increased. Other serum parameters showing changes after carbon tetrachloride were: bilirubin, proteins, cholesterol, triglycerides and lipoprotein-X. Picroliv (from the plant Picrorhiza kurroa) in doses of 6 and 12 mg/kg provided a significant protection against most of the biochemical alterations produced by carbon tetrachloride. The degree of protection afforded by picroliv, when administered simultaneously or as a pretreatment was almost equal.


Assuntos
Animais , Tetracloreto de Carbono/antagonistas & inibidores , Cinamatos/farmacologia , Enzimas/sangue , Glicosídeos/farmacologia , Metabolismo dos Lipídeos , Fígado/efeitos dos fármacos , Masculino , Extratos Vegetais/farmacologia , Ratos , Ácido Vanílico/farmacologia
2.
Artigo em Inglês | IMSEAR | ID: sea-19141

RESUMO

Administration of picroliv, a standardized fraction of alcoholic extent of Picrorhiza kurroa (3-12 mg/kg/day for two weeks) simultaneously with P. berghei infection showed significant protection against hepatic damage in Mastomys natalensis. The increased levels of serum glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase, lipoprotein-X (LP-X) and bilirubin in the infected animals were marked reduced by different doses of picroliv. In the liver, picroliv decreased the levels of lipid peroxides and hydroperoxides and facilitated the recovery of superoxide dismutase and glycogen. Picroliv had no effect on the degree of parasitaemia.


Assuntos
Animais , Cinamatos/uso terapêutico , Glicosídeos/uso terapêutico , Hepatopatias Parasitárias/prevenção & controle , Malária/complicações , Masculino , Muridae , Extratos Vegetais/uso terapêutico , Plasmodium berghei , Ácido Vanílico/uso terapêutico
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