Interaction of capsaicin with mixed function oxidases: exvivo and in-vivo studies

Capsaicin was recently found to alter the in-vitro biphenyl hydroxylation by the 9000 xg supernatent of the liver homogenate of rats. The present work aims at evaluating the effect of subcutaneously administered capsaicin on the ex-vivo metabolism of biphenyl in rats. The produced changes were compared with that of enzyme induction by phenobarbital. In addition, the in-vivo effect of capsaicin on drug metabolism was evaluated by use of the model of hexobarbital sleeping time. It is concluded that subcutaneous administration of capsaicin produces marked activation of drug metabolising enzymes

Effect of capsaicin on mixed function oxidases - an in vitro study

The effect of capsaicin on mixed function oxidases was studied by use of liver homogenates of adult female rats. Hydroxylation of biphenyl was taken as the assay system. Capsaicin was found to produce a prominent concentration-dependent activation of the 4-hydroxylation reaction. The 2-hydroxylation reaction showed an inhibition in presence of capsaicin. The results indicate that capsaicin may interact with more than one form of cytochrome P. 450