[Juvenile Sapho a two cases reports]

The acronym Sapho syndrome [for synovitis, acne, pustulosis, hyperostosis, osteitis] is a rare entity, particulary in pediatric patients. A 15 year-old and 19 year-old adolescents, with severe acne history, presented inflammatory buttock pain associated to lumbar pain in the first case and sternal pain in the second. Radiographic exploration demonstrated bilateral sacro-iliitis associated to sterno-clavicle arthritis in the second case. Diagnosis of Sapho syndrome was retained. Satisfactory improvement was caused by corticosteroids in the first case and non steroidal anti-inflammatory drugs in the second. Sapho syndrome is rare disease with unknown origin. Non steroidal anti-inflammatory drugs are the treatment of choice, as they are usually both effective and well tolerated