T lymphocyte subpopulations in peripheral blood of patients with Alopecia areata

Twenty patients [15 males and 5 females] suffering from alopecia areata in different sites were examined and counts of total T-cell, T- helper and T-suppressor cells were determined by using monoclonal antibodies [OKT3, OKT4 and OKT8, respectively]. Results showed that there is a decrease of total T-cell in alopecia areata patients as compared with control subjects which was explained by several factors one of which is suppressed cell mediated immunity. The count of T-helper cells was nonsignificant, while T-suppressor cell count was significant lower than control subjects and T-helper/T- suppressor ratio was significantly increased supporting the hypothesis of autoimmune etiology

Prurigo of hebra: a clinical histological and immunological study

Prurigo of Hebra is a chronic pruritic papular skin disease of unknown etiology. The disease affects mainly children and rarely extends into adulthood. The disease is now rarely diagnosed. Very few facts are known about such a condition. Clinical studies and histopathological examination of biopsies from skin lesions and associated lymph node enlargement besides immunological studies for the serum level of immunoglobulins were done for 25 cases. Findings point to the condition of being a possible unusual manifestation of atopy as evidenced by a significant rise of IgE serum level than in control subjects