[ effects of probiotic supplementation on glycemic control, insulin resistance and inflammatory biomarkers of type 2 diabetic patients]

Introduction: Systemic inflammation plays a main role in the incidence of diabetes complications. Probiotics can be used in the treatment of diabetes complications for its anti-inflammatory properties. This study aimed to investigate the effects of probiotic supplement on glycemia, insulin resistance and inflammatory markers in patients with type 2 diabetes

Materials and Methods: This randomized double blind clinical trial was carried out on 59 diabetic patients, aged 25-65 years, referred to the Taleghani Hospital in Tehran. They were randomly divided in 2 groups, the probiotic and the placebo. Patients in each group received 2 capsules per day for 6 weeks. Fasting blood samples were taken at baseline and after intervention to evaluate glycemic control, insulin resistance and inflammatory biomarkers

Results: Mean fasting blood glucose was significantly decreased by 9% [132.7 +/- 34 vs. 146.5 +/- 44] in the probiotic group during the intervention [P=0.001]. Results of the analysis of covariance showed that there were statistically significant differences between the two groups in fasting blood glucose and insulin resistance, whereas there were none observed in IL-6 and TNF alpha between the two groups after intervention

Conclusions: The results of the present study indicate that probiotic consumption may help in diabetes control through reducing glycemia and insulin resistance

Role of probiotics in glycemic controls and body weight in type 2 diabetes: a systematic of human and animal studies

Publications evaluating the effects of probiotics on glycemic parameters, body weight change and food intakes have increased steadily in recent years. This study hence assessed all related human and animal studies. In the present systematic review, we used search engines to collect relevant data until May 2014, concerning the effects of probiotics on body weight changes, fasting plasma glucose [FPG], oral glucose tolerance test [OGTT], glycated hemoglobin [HbA1c], insulin, and insulin resistance in T2DM. Twenty-five animal and four human articles met our inclusion criteria, articles which generally reported positive effects of probiotics on glycemic parameters. Lactobacillus sub-strains were used in all studies except for one. Most of the human and animal studies reported significant reduction in FPG and delay in the onset of T2DM, respectively; only animal studies reported significant reduction in OGTT. Few studies showed significant reduction and increase in HbA1c and insulin levels, respectively. Most studies reported significant increment in body weight after intervention, whereas only a few reported significant reductions in this parameter. This study showed that the administration of probiotics have beneficial effects on glycemic parameters, although their effects on body weight were inconsistent. Therefore, considering the controversial results among human and animal reports, more data evidence is needed to conduct a meta-analysis