Renal changes after co-administration of verapamil with acetyl salicylic acid or diclofenac

The effect of chronic co-administration of verapamil with either acetyl salicylic acid [ASA] or diclofenac were investigated on renal function parameters [serum urea and creatinine] and histopathologic changes that occur in the kidney. Also, urinary prostaglandin PGE2 changes were studied to uncover the possible protective effect of calcium channel blocker upon untoward renal effects of NSAIDs. Although chronic oral administration of verapamil alone increased, PGE2 level in urine of rats, yet, it did not induce any significant change on serum urea, creatinine or renal histopathology