RESUMO
We examined the capacity of high-intensity intermittent training (HI-IT) to facilitate the delivery of lipids to enzymes responsible for oxidation, a task performed by the carnitine palmitoyl transferase (CPT) system in the rat gastrocnemius muscle. Male adult Wistar rats (160-250 g) were randomly distributed into 3 groups: sedentary (Sed, N = 5), HI-IT (N = 10), and moderate-intensity continuous training (MI-CT, N = 10). The trained groups were exercised for 8 weeks with a 10% (HI-IT) and a 5% (MI-CT) overload. The HI-IT group presented 11.8% decreased weight gain compared to the Sed group. The maximal activities of CPT-I, CPT-II, and citrate synthase were all increased in the HI-IT group compared to the Sed group (P < 0.01), as also was gene expression, measured by RT-PCR, of fatty acid binding protein (FABP; P < 0.01) and lipoprotein lipase (LPL; P < 0.05). Lactate dehydrogenase also presented a higher maximal activity (nmol·min-1·mg protein-1) in HI-IT (around 83%). We suggest that 8 weeks of HI-IT enhance mitochondrial lipid transport capacity thus facilitating the oxidation process in the gastrocnemius muscle. This adaptation may also be associated with the decrease in weight gain observed in the animals and was concomitant to a higher gene expression of both FABP and LPL in HI-IT, suggesting that intermittent exercise is a "time-efficient" strategy inducing metabolic adaptation.
Assuntos
Animais , Masculino , Ratos , Carnitina O-Palmitoiltransferase/metabolismo , Músculo Esquelético/enzimologia , Condicionamento Físico Animal/fisiologia , Adaptação Fisiológica/fisiologia , Lipase Lipoproteica/metabolismo , Músculo Esquelético/metabolismo , Músculo Esquelético/fisiologia , Oxirredução , Distribuição Aleatória , Ratos Wistar , Reação em Cadeia da Polimerase em Tempo Real , Reação em Cadeia da Polimerase Via Transcriptase ReversaRESUMO
Foi revisada a experiência multi-institucional dos autores nessa doença rara, enfatizando seu tratamento e resultado
Assuntos
Ameloblastoma , Fíbula , Mandíbula , MaxilaRESUMO
O registro da atividade elétrica doo estômago, através da detecção do campo magnético associado foi detectado. A comparação desta atividade através do registro simultâneo do sinal elétrico e magnético foi feita através da função de correlação, análise de Fourier e testes estatísticos. A medida desta atividade pode auxiliar no diagnóstico de patologias do trato gastrointestinal. O método magnético apresenta a vantagem de ser completamente não invasivo.
Abstract - This work shows the study of the stomach electrical activity by the measurement of the magnetic field produced by the electrical currents generated at the stomach. A comparison between the electric and magnetic measurements was performed by the correlation function, Fourier analysis and statistical tests. These measurements can help on diagnostic of gastric-intestinal pathologies. This method has the advantage of the being non invasive