Comparative study of non-steroidal anti-inflammatory drugs [NSAIDs] and their interaction with drugs affecting prostaglandins

This experimental study was carried out to evaluate the possible therapeutic and toxic effects of a more or less recent non-steroidal anti-inflammatory drug [NSAID], tenoxicam, in management of rheumatoid arthritis model in rats in comparison with indomethacin, being a standard one and piroxicam as a member of its group [oxicams]. In addition, a possible interaction between tenoxicam and both the anti- hypertensive drugs, captopril and clonidine, was also studied. This study was carried out in rats in which rheumatoid like-arthritis was induced experimentally by collagen II and complete Freund's adjuvant mixture

Interaction between butorphanol, pentazocine and digitalis on the cardiovascular system, experimental study

In the present work, an experimental study of the possible interactions between digoxin and two opioids [pentazocine and butourphanol] on the cardiovascular system was conducted both in vivo and in vitro. l. V. injection of pentazocine or butorphanol produced a significant hypodigitalised as well as in intravenously or orally digitalized dogs, with no effect on electrocardiographic tracings. Each of these opioids when administered alone or with digoxin infusion to the isolated rabbit heart was found to induce significant decrease of the myocardial contractility but no changes in the mean coronary flow. The possible mechanisms underlying these interactions were discussed, and it could be concluded that pentazocine or butorphanol must be used cautiously during digitalis therapy owing to their potential negative inotropic and hypotensive effects

Assessment of the anti-inflammatory action of some drugs

The aim of the present work was a study of the acute toxicity, the anti-inflammatory activity as the analgesic potency of salicylates, oxyphenbutazone, hydrocortisone and propranolol The L.D[50] was found to be 300 mg/kg., 460 mg/kg., 750 mg/kg. and 36 mg/kg respectively. All tested drugs induced a significant anti-inflammatory activity sod. Salicylate was the most potent, while propranolol was the least effective one. Sod. salicylate, hydrocortisone and oxyphenbutazone exerted a significant analgesic activity following the hot plate method, but by using the tail compression test only sod. salicylate exerted analgesic activity

Comparative toxicological study of some antibilharzial drugs

The data obtained in this work could be summarized as follows: 1. The LD 50 of tartar emetic was 49/kg, it produced a significant reduction of haemoglobin content and haematocrite value. It was the most toxic drug to the heart and lungs. Pharmacological studies showed that it produced direct depression on the isolated rabbits, heart, a perasympathomimetic effect manifested on isolated rabbits, intestine and blood pressure of anaesthetized dogs. 2. The LD 50 of astiban was 290 mg/kg. The results of subacute toxicity tests were similar to those obtained with tartar emetic but it was devoid of any toxic effect on heart. Pharmacological studies showed that it produced parasyupathomimetic effect on isolated rabbit's heart. 3. LD 50 of Hycanthone was 57 mg/ kg. No effect on the blood picture of rats was observed it was more toxic to the liver. It produced direct cardiac inhibition on the isolated rabbit's hearts, parasympathomimetic effect on the isolated rabbit's intestine and blood pressure of dog. 4. LD 50 of niridazole was 990 mg/ kg. The results of subacute toxicity tests were similar to those obtained with hycanthone. It is more toxic to brain it produced direct cardiac inhibition on the rabbit's heart and hypotension in dog