RESUMO
In the maternal circulation lipid peroxides contribute to the maternal endothelial dysfunction which is responsible for all the systemic manifestations of preeclampsia including hypertension and proteinuria. In preeclampsia there is hyperlipidemia and hyper-triglycerdemia which aids the production of lipids peroxides. Malondialdehyde [MDA] is an important biomarker of lipid peroxides. The aim of this work is to study the relation between seric triglycerides and MDA with the outcome of pregnancy in preeclampsia. A case control study included 20 cases of normal pregnancy and 44 cases of preeclampsia. Estimation of seric triglycerides and MDA for both control group and preeclamptic patients were done. Estimation of seric triglycerides and MDA for both control group and preeclamptic patients showed that the average seric triglycerides were 179.35 +/- 41.33 mg/dl in normal pregnancy and 271.32 +/- 18.61 mg/dl in preeclamptic patients [P<0.05]. Average seric MDA in normal pregnancy was 1.54 +/- 0.18 nmol/ml and 2.73 +/- 0.43 nmol/ml in preeclampsia [P<0.05]. When the blood pressure [BP] was < 150/100 average seric triglycerides was 242.48 +/- 4.20 mg/dl and MDA was 2.4 +/- 0.30 nmol/ml. When the BP was >/= 150/100 average seric triglycerides and MDA were 281.45 +/- 3.6 mg/dl and 3.12 +/- 0.8 nmol/ml respectively. The differences between the two groups were significance [P<0.05]. When the gestational age at delivery was < 34 weeks average seric triglycerides and MDA were 359.54 +/- 5.9 mg/dl and 3.11 +/- 0.8 nmol /ml respectively. When the gestational age at delivery was < 34 weeks average seric triglycerides and MDA were 271.65 +/- 4.2 mg/dl and 2.1 +/- 0.3 nmol/ml respectively. The differences between groups were significant [P< 0.05]. When the birth weight was < 2500 gm average seric triglycerides and MDA were 360.53 +/- 6.8 mg/dl and 3.22 +/- 0.9 nmol/ml respectively. When the birth weight was >/= 2500gm average seric triglycerides and MDA were 261.15 +/- 3.2 mg/dl and 2.2 +/- 0.3 nmol/ml respectively. The differences between groups were significant [P < 0.05]. When the newborn needed admission to the neonatal intensive care unit [NICU] for resuscitation average seric triglycerides and MDA were 342.15 +/- 14.4 mg/dl and 3.2 +/- 0.5 nmol/ml respectively. When the newborns did not need admission to the NICU for resuscitation average seric triglycerides and MDA were 241.20 +/- 2.5 mg/dl and 1.8 +/- 0.4 nmol/ml respectively. The differences between groups were significant [P < 0.05]. These results prove that the average seric levels of triglycerides and MDA are in direct proportion to the degree of severity of preeclampsia and consequently to the perinatal outcome in these cases