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Braz. j. med. biol. res ; 35(10): 1183-1193, Oct. 2002. tab, graf
Artigo em Inglês | LILACS | ID: lil-326229

RESUMO

We have evaluated the cellular and humoral immune response to primary respiratory syncytial virus (RSV) infection in young infants. Serum specimens from 65 patients <=12 months of age (39 males and 26 females, 28 cases <3 months and 37 cases > or = 3 months; median 3 ± 3.9 months) were tested for anti-RSV IgG and IgG subclass antibodies by EIA. Flow cytometry was used to characterize cell surface markers expressed on peripheral blood mononuclear cells (PBMC) from 29 RSV-infected children. There was a low rate of seroconversion in children <3 months of age, whose acute-phase PBMC were mostly T lymphocytes (63.0 ± 9.0 percent). In contrast, a higher rate of seroconversion was observed in children >3 months of age, with predominance of B lymphocytes (71.0 ± 17.7 percent). Stimulation of PBMC with RSV (2 x 10(5) TCID50) for 48 h did not induce a detectable increase in intracellular cytokines and only a few showed a detectable increase in RSV-specific secreted cytokines. These data suggest that age is an important factor affecting the infants' ability to develop an immune response to RSV


Assuntos
Humanos , Masculino , Feminino , Lactente , Recém-Nascido , Linfócitos B , Citocinas , Infecções por Vírus Respiratório Sincicial , Vírus Sincicial Respiratório Humano , Linfócitos T , Fatores Etários , Anticorpos Antivirais , Antígenos de Superfície , Biomarcadores , Brasil , Citometria de Fluxo , Técnicas Imunoenzimáticas
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