Resistance to imipenem in clinical isolates of kiebsiella pneumoniae and proteus mirabilis

Six Klebsiella pneumoniae and seven Proteus mirabilis clinical isolates were multiple drug resistant producing beta-lactamases. Out of the thirteen isolates, eight were resistant to third generation cephalosporin, cefotaxime and one was of intermediate resistance. Similarly, five isolates were resistant to fourth generation cephalosporin, cefepime with another five of intermediate resistance. However, isolates showed high alarming resistance pattern against imipenem and meropenem antibiotics. A representative imipenem resistant isolate from both strains were picked out for the detection of 40 kDa outer membrane protein and plasmid profile