Factors associated with intraoperative hypothermia in elderly patients and management strategies / 中华老年医学杂志

Objective To investigate the incidence of intraoperative hypothermia in elderly patients,and to analyze and discuss related influencing factors and targeted management strategies.Methods From February 2017 to February 2019,220 elderly patients admitted into our hospital for surgery were selected.According to whether or not they had intraoperative hypothermia,patients were divided into the hypothermia group and the non-hypothermia group.General information and surgical data were compared between the two groups.Measures for the prevention of intraoperative hypothermia were discussed.Results Of the 220 patients,103 had intraoperative hypothermia,and the incidence rate was 46.8％.The proportion of patients aged ≥70 years or with BMI ＜24 kg/m2 was higher in the hypothermia group than in the non-hypothermia group (all P ＜ 0.05).The proportion of patients with the anesthesia time ≥60 min or total intraoperative fluid intake ≥2000 ml was higher in the hypothermia group than in the non-hypothermia group(all P＜0.05).BMI ＜24 kg/m2 and total intraoperative fluid intake ≥ 2000 ml were the key risk factors for intraoperative hypothermia in elderly patients(all P＜0.05).Conclusions Intraoperative hypothermia is a common complication for elderly patients undergoing surgery.Intraoperative fluid intake and body mass are the key risk factors for intraoperative hypothermia.Targeted treatment measures based on the above related factors should be considered for elderly patients receiving surgery.

Experimental research ofHaizao-Xiangsheng mixture in the treatment of chronic pharyngitis / 国际中医中药杂志

ObjectiveTo observe the effect ofHaizao-Xiangsheng mixture on signs and symptoms, blood index and tissue pathology of rabbit models with chronic pharyngitis.Methods60 Japanese white rabbits by random grouping method were divided into normal control group, model group, positive control group andHaizao- Xiangsheng mixture with high, medium and low dose group, with 10 rats in each group. Except the normal control group, rabbits in other groups were performed spraying ammonia in pharyngeal portion and submucosal injection of turpentine oil preparation to create chronic pharyngitis models. TheHaizao- Xiangsheng mixture, high, medium and low dose group were treated withHaizao-Xiangsheng mixture of 42, 21, 10.5 g/kg, the positive control group was treated with watermelon frost Runhou tablet suspension 5.04 g/kg, the normal control group and model group were treated with the same volume of saline. Animal signs and symptoms were recorded daily (including general conditions and temperature). After continuous administration of 7 days, red blood cell count (RBC), white blood cell count (WBC), percentage of neutrophils (N%), the percentage of mononuclear cells (M%) and percentage of lymphocytes (L%) were detected to observe the histological change of pharyngeal mucosa and lower tissue pathology.ResultsAfter administration, compared with the model group, high dose group ofHaizao-Xiangsheng mixture rabbit body temperature dropped (38.90 ± 0.21℃ vs. 39.23 ± 0.39℃,P< 0.05), WBC (10.1 ×1012/L ± 1.73 ×1012/Lvs. 13.1 ×1012/L ± 1.69 ×1012/L) decreased, and RBC increased (5.73 ×109/L ± 0.59 ×109/Lvs.5.19 ×109/L ± 0.43 ×109/L,P<0.01).ConclusionsHaizao-Xiangsheng mixture can improve signs and symptoms, hematology indexes and histopathological changes of the experimental rabbit models of chronic pharyngitis.

Effects of Danhong mixture on water and calcium content in brain tissue of rats with acute cerebral ischemia reperfusion injury / 国际中医中药杂志

Objective To Study the effects of Danhong mixture on water and calcium contents in brain tissue of rats with acute cerebral ischemia reperfusion injury.Methods 60 healthy SD rats were randomly divided into 6 groups,respectively,a sham operation group,a model control group,and 4 drug treatment groups.Models of cerebral ischemia reperfusion injury were established by 4 blood-vessel method,and administrated with different doses of Danhong mixture injection and compound salvia miltiorrhiza injection.Effects of Danhong mixture on water and calcium content in brain tissue of rats with acute cerebral ischemia and reperfusion injury were observed.Results Water and calcium content in brain tissue of rats with acute cerebral ischemia reperfusion injury were significantly decreased in Danhong mixture of high dose group (P＜0.01),(water was 75.84％ and calcium was 114.56 μg/g).Water and calcium content were also significantly decreased in Danhong mixture of medium dose group (P＜0.01),(water was 80.13％ and calcium was 132.35 μg/g)Water and calcium content showed decreasing tendency in Danhong mixture of low dose group,but without statistical significance,its numerical value was respectively 73.94％ and 106.32 μg/g.Conclusion Danhong mixture can reduce water and calcium content in brain tissue of rats with acute cerebral ischemia reperfusion injury,which indicated its neuroprotective effects.