RESUMO
Seborrheic keratosis is a common benign epithelial tumor which occurs primarily on sun-exposed area, and is occasionally associated with several malignant or premalignant conditions. Among these malignant or premalignant conditions, Bowen disease and basal cell carcinoma are common, but still it is not clear whether these malignancies arise incidentally with seborrheic keratosis or malignant transformation has occurred. We herein report a case of Bowen disease with seborrheic keratosis on the inguinal area where prior seborrheic keratosis had recurred after incomplete removal.
Assuntos
Doença de Bowen , Carcinoma Basocelular , Ceratose SeborreicaRESUMO
BACKGROUND: The use of growth factors in skin rejuvenation is emerging as a novel anti-aging treatment. While the role of growth factors in wound healing is well established, their use in skin rejuvenation has only recently been to be studied and no controlled trials have been performed. OBJECTIVE: We evaluated the anti-aging effects of secretory factors of endothelial precursor cells differentiated from human embryonic stem cells (hESC-EPC) in Asian skin. METHODS: A total of 25 women were included in this randomized, controlled split-face study. The right and left sides of each participant's face were randomly allocated to hESC-EPC conditioned medium (CM) or saline. To enhance epidermal penetration, a 0.25-mm microneedle roller was used. Five treatment sessions were repeated at 2-week intervals. RESULTS: Physician's global assessment of pigmentation and wrinkles after treatment revealed statistically significant effects of microneedling plus hESC-EPC CM compared to microneedling alone (p<0.05). Skin measurements by Mexameter and Visiometer also revealed statistically significant effects of microneedling plus hESC-EPC CM on both pigmentation and wrinkles (p<0.05). The only minimal adverse event was mild desquamation in one participant. CONCLUSION: Secretory factors of hESC-EPC improve the signs of skin aging and could be a potential option for skin rejuvenation.
Assuntos
Feminino , Humanos , Envelhecimento , Povo Asiático , Meios de Cultivo Condicionados , Células-Tronco Embrionárias , Peptídeos e Proteínas de Sinalização Intercelular , Pigmentação , Rejuvenescimento , Envelhecimento da Pele , Pele , Células-Tronco , CicatrizaçãoRESUMO
No abstract available.
Assuntos
Adenocarcinoma , Diagnóstico , Neoplasias Pulmonares , Pulmão , Metástase NeoplásicaRESUMO
No abstract available.