RESUMO
<p><b>OBJECTIVE</b>To evaluate the operative indication, the choice of valve prostheses, and the method of anticoagulation therapy of tricuspid valve replacement (TVR).</p><p><b>METHODS</b>From May 1998 to January 2008, 70 patients underwent TVR. There were 59 cases of rheumatic heart diseases. The operations included mitral and tricuspid valve replacement for 37 cases, triple valve replacement for 18 cases, isolated TVR for 13 cases, and tricuspid and aortic valve replacement for 2 cases. All the patients received oral anticoagulant therapy (warfarin) 2 d after the operations.</p><p><b>RESULTS</b>There were 3 in-hospital deaths (4.3%) and 1 late death (0.4%). The follow-up rate was 88.1%, and the cumulative follow-up was 243.5 patient-years (pty). The anticoagulation-related event rate was 2.9% pty, and the mean INR value of 643 out-patient samples was 1.87 +/- 0.68. Post-operative heart function NYHA classification: 52 cases in class I to II, and 7 cases in class III.</p><p><b>CONCLUSIONS</b>TVR should be indicated for severely damaged and deformed tricuspid valve of rheumatic heart diseases. Bileaflet mechanical valve is a suitable prosthesis for TVR. The optimal anticoagulation therapy intensity of TVR needs to be investigated.</p>
Assuntos
Adolescente , Adulto , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Anticoagulantes , Usos Terapêuticos , Seguimentos , Próteses Valvulares Cardíacas , Implante de Prótese de Valva Cardíaca , Cuidados Pós-Operatórios , Resultado do Tratamento , Valva Tricúspide , Cirurgia Geral , Varfarina , Usos TerapêuticosRESUMO
The enzyme histochemistry method was used in this experiment to study the biocompatibility of the UV surface modified Dacron. The activity of the enzymes such as ALP, ACP, NADHD and LDH in the tissue surrounding both the modified and unmodified materials after a certain implantation period was semiquantitatively measured. The results showed that the biocompatibility of the surface modified Dacron was as good as that of the unmodified one.
Assuntos
Materiais Biocompatíveis , Próteses Valvulares Cardíacas , Teste de Materiais , Polietilenotereftalatos , Efeitos da Radiação , Propriedades de Superfície , Raios UltravioletaRESUMO
Mechanical environment seems to be one of the most important surviving environment for vessel conduit and vascular endothelial cells(ECs), while adhesion is one of the most important physical characteristics of ECs. In this study, Flow chambers of steady laminar and turbulent flow are made and improved. Different flow-derived VCAM-1, ICAM-1 expressions are detected by laser confocal microscope. Spacial and temporal curves of the adhesion molecules are protracted. In laminar flow, expression of VCAM-1 is dramatically elevated, whereas the expression of ICAM-1 is transiently elevated and it immediately falls back to the baseline. In turbulent flow, expression of VCAM-1 declines, while expression of ICAM-1 slowly rises to a peak. These results indicate that such pathological flow field as turbulence exerts different influence on the adhesion of vascular ECs from laminar flow, and turbulence could be one of the most important reasons of the ECs structural and functional lesion.
Assuntos
Humanos , Adesão Celular , Células Cultivadas , Endotélio Vascular , Biologia Celular , Metabolismo , Células Epiteliais , Biologia Celular , Metabolismo , Molécula 1 de Adesão Intercelular , Microscopia Confocal , Estresse Mecânico , Veias Umbilicais , Biologia Celular , Molécula 1 de Adesão de Célula VascularRESUMO
0.05,vs control).Insulin stimulated glucose transport into cardiomyocytes in a dose-dependent fashion.Glucose uptake stimulated by insulin into cardiomyocytes was both decreased significantly in 15 mins reperfusian group and in 60 mins reperfusion group (P