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Objective To analyze the research status and predict the development trend of clinical comprehensive evaluation of drugs in China, and to provide reference for clinical comprehensive evaluation. Methods CNKI, Wanfang and VIP database were used to search the published articles of clinical comprehensive evaluation. Literature searching was set from the building time of the database to 2022, the basic information about the published articles was obtained for the evaluation of the literature quality. Bibliometrics and CiteSpace 6.1.R3 software were used to visualize the research authors, research institutions, and key words. Results After data screening, a total of 126 Chinese published articles were selected. The analysis showed that the numbers of published articles were rising continuously, and China Academy of Chinese Medical Sciences and Xie Yanming were the institute and the author with the maximum number of literatures, respectively. Conclusion The clinical comprehensive evaluation of drugs was conducted based on the clinical value of drugs, guided by the policy requirements. It is suggested that researchers should conduct the comprehensive evaluation according to the focus and requirements of government agencies, the pharmaceutical industry and the clinical applications.
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Objective To investigate the current situation and existing problems of community chronic disease management in China and provide a theoretical basis for community chronic disease management to reduce the mortality and economic burden. Methods Research papers on community chronic disease management published in Chinese academic journal network from January 2010 to January 2020 were selected. Literature co-occurrence analysis system software, Bicomb2.0, and SPSS were used for data extraction and analysis based on publication years, geographical distribution, funding sources, etc. Results 1 427 papers were included. Most papers were published in the recent three years (2017—2019), with an average of 206.7 papers per year. 1 347 papers in Chinese (94.4%) and 80 in English (5.6%) were published in 436 journals, and 24.5% were funded. Hot topics are community health services, health management, diabetes and hypertension management, influencing factors. Conclusion Community chronic disease management has drawn a lot of attention in China. Economically well-developed provinces invested more on community chronic disease management. Universities are the main research institutions. Most researches are still at the exploratory stage.
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Objective To investigate the effect of formative assessment on skill acquisition of basic life support (BLS) among medical students. Methods Totally 206 undergraduates were ran-domized into control group (C group) and interventional group (F group). A BLS lecture was given in both groups. And then, 45 min BLS training and BLS skill assessment (after training) were given in C group. Undergraduates in F group received BLS skill assessment (formative assessment) before training, and 15 min feedback was delivered based on the assessment, then 30 min BLS training was conducted. Skills assessment was conducted again in F group after the training. Student's-t-test was used to compare the difference of skills between the two groups and P<0.05 signifies statistically sig-nificant differences. Results Score of F group (85.2±7.3) were higher than that in C group (68.2± 13.2), with statistical difference. Conclusion A formative assessment could significantly improve skill acquisition of BLS among medical students.
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OBJECTIVE:To establish a HPLC method for content determination of forsythin in Qingrejiedu granules.ME_ THODS:A Alltech Inersil ODS-2column(150mm?4.6mm,5?m)was used,the mobile phase was acetonitrile-water(18∶32), the detective wavelength was277nm,the column temperature was30℃,the flow rate was1.0ml/min.RESULTS:The linear range of forsythin was0.0984?g～12.3?g(r=0.9997),the average recovery was100.62%(RSD=0.6%).CONCLUSION:This method was easy to operate,good reproducibility and accurate result,it can be used for quality control in production Qin?grejiedu granules.
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Objective: To develop a method to determine the content of a berberine hydrochloride in Xiao A Lotion. Methods: HPLC was used to determine the content of berberine hydrochloride in Xiao A Lotion. The separation was performed on Inertsil ODS 3 column with 0.05mol/L NaH 2PO 4 (pH3.0) acetonitrile (70∶30) as a mobile phase and the wavelength of UV detector was 270nm. Results: The Linearity of this method was well with the average recovery of 101.4%. Conclusion: The method is simple, reliable, and sensitive. It also shows good separating degree. It can be used in quality control of Xiao A Lotion.