RESUMO
@#The role of extracellular vesicles (EV) in osteoarthritis has become the focus of much research. These vesicles were isolated from several cell types found in synovial joint including chondrocytes and synovium. As articular cartilage is an avascular tissue surrounded by synovial fluid, it is believed that EV might play a crucial role in the homeostasis of cartilage and also could hold key information in the pathogenesis of osteoarthritis. This is thought to be due to activation of pro-inflammatory factors leading to a catabolic state and degradation of cartilage. In addition, due to the nature of articular cartilage lacking neuronal innervation, knowledge of EV can contribute to identification of novel biomarkers in this debilitating condition. This can be either directly isolated from aspirate of synovial fluid or from peripheral blood. Finally, EVs are known to shuttle important signalling molecules which can be utilised as unique modality in transferring therapeutic compounds in a cell free manner.
RESUMO
Está revisión literaria determinó que la familia es el núcleo de la sociedad, es en ella donde se satisfacen las necesidades básicas de cada ser humano en todos los aspectos. Por lo tanto el objetivo trazado en la investigación fue el análisis de la repercusión de la vida familiar en las personas y la sociedad; al igual que describir las necesidades que debe satisfacer la familia para el buen desarrollo de los individuos. El tipo de investigación fue una revisión de literatura de tipo documental, en el que se llegó a la conclusión que es en la familia donde primero se satisfacen las necesidades fisiológicas, de seguridad, además de brindar la educación para que cada miembro de la familia pueda convivir con otros de manera saludable, además de darle un pilar en el cual el individuo pueda tener éxito y autorrealización. Esto significa que tener individuos saludables repercutirá en la sociedad, creando una población saludable.
This research has determined that family is the center of society, there is where every basic needs of every human being are fully satisfied. Therefore the principal aim of this study was the analysis of the repercussion of the family lifestyle into people and society; just as describing the needs that a family must satisfied to assure the correct and well development of a human being. This was a documentary research, in which was reach to the conclusion that is within the family where physiological and safety needs are first satisfied, as well as provide the education so that each member of the family can live with others in a healthy way, besides giving them the pillars to achieve success and self-fulfillment. This means that having healthy human beings will be reflected in society by developing a healthy population.