RESUMO
In the present study, the frequency of research misconduct in Korean medical papers was analyzed using the similarity check software iThenticate®. All Korean papers written in English that were published in 2009 and 2014 in KoreaMed Synapse were identified. In total, 23,848 papers were extracted. 4,050 original articles of them were randomly selected for similarity analysis. The average Similarity Index of the 4,050 papers decreased over time, particularly in 2013: in 2009 and 2014, it was 10.15% and 5.62%, respectively. And 357 (8.8%) had a Similarity Index of ≥ 20%. Authors considered a Similarity Index of ≥ 20% as suspected research misconduct. It was found that iThenticate® cannot functionally process citations without double quotation marks. Papers with a Similarity Index of ≥ 20% were thus individually checked for detecting such text-matching errors to accurately identify papers with suspected research misconduct. After correcting text-matching errors, 142 (3.5% of the 4,050 papers) were suspected of research misconduct. The annual frequency of these papers decreased over time, particularly in 2013: in 2009 and 2014, it was 5.2% and 1.7%, respectively. The decrease was associated with the introduction of CrossCheck by KoreaMed and the frequent use of similarity check software. The majority (81%) had Similarity Indices between 20% and 40%. The fact suggested that low Similarity index does not necessarily mean low possibility of research misconduct. It should be noted that, although iThenticate® provides a fundamental basis for detecting research misconduct, the final judgment should be made by experts.
Assuntos
Publicações Duplicadas como Assunto , Políticas Editoriais , Ética , Julgamento , Publicações Periódicas como Assunto , Plágio , Publicações , Má Conduta Científica , SinapsesRESUMO
PURPOSE: Hemorrhagic metastatic brain tumors are not rare, but little is known about the surgical outcome following treatment. We conducted this study to determine the result of the surgical outcome of hemorrhagic metastatic brain tumors. MATERIALS AND METHODS: From July 2001 to December 2008, 21 patients underwent surgery for hemorrhagic metastatic brain tumors at our institution. 15 patients had lung cancer, 3 had hepatocellular carcinoma, and the rest had rectal cancer, renal cell carcinoma, and sarcoma. 20 patients had macroscopic hemorrhage in the tumors, and one patient had intracerebral hemorrhage surrounding the tumor. A retrospective clinical review was conducted focusing on the patterns of presenting symptoms and signs, as well as local recurrence following surgery. RESULTS: Among 21 hemorrhagic brain metastases, local recurrence developed in two patients. The 12 month progression free survival rate was 86.1%. Mean time to progression was 20.8 months and median survival time after surgery was 11.7 months. CONCLUSION: The results of our study showed that hemorrhagic metastatic brain tumors rarely recurred after surgery. Surgery should be considered as a good treatment option for hemorrhagic brain metastasis, especially in cases with increased intracranial pressure or severe neurologic deficits.
Assuntos
Humanos , Encéfalo , Neoplasias Encefálicas , Carcinoma Hepatocelular , Carcinoma de Células Renais , Hemorragia Cerebral , Intervalo Livre de Doença , Hemorragia , Pressão Intracraniana , Neoplasias Pulmonares , Metástase Neoplásica , Recidiva Local de Neoplasia , Manifestações Neurológicas , Neoplasias Retais , Recidiva , Estudos Retrospectivos , SarcomaRESUMO
Assuntos
Artrite , Condrócitos , Colágeno Tipo II , Colagenases , Matriz Extracelular , Injeções Intra-Articulares , Cetorolaco , Modelos Animais , Osteoartrite , Papaína , Articulação TemporomandibularRESUMO
Assuntos
Animais , Coelhos , Cálcio , Fêmur , Compostos de Mostarda Nitrogenada , OsseointegraçãoRESUMO