Seleçäo por meio de células KB de substâncias e extratos potencialmente ativos em quimioterapia do câncer / Selection by means of KB cells of substances and extracts potentially active in cancer chemotherapy

Several synthetic, semi-synthetic and natural compounds as well extracts were screened for their growht inhibition activity on KB cells. The most active ones were naphthoquinones and derivatives of pyrido [4,3-b] carbazole alkaloids, with inhibition dose (ID50) < 4microng/ml. Of the crude extracts of several plants screened, Vellozia caput-ardeae showed to be the most active