Correlation of HER2/neu over expression, p53 protein accumulation and steroid receptor status with tumor characteristics: an Iranian study of breast cancer patients

Molecular biomarkers are valuable in evaluation the course of malignancies. In this study, the relationship between HER2/neu, p53, steroid receptors and clinicopathological features of patients with breast cancer has been assessed. Three hundred thirty nine women with a primary diagnosis of breast cancer from 2001 to 2006 were included. They were evaluated for tumor features. The content of the steroid hormone receptors and expression of HER2/neu and p53 was also examined by immunohistochemistry assay. From patients arrived at this study, 52%, 36%, 46.5% and 44% were positive for HER2/neu, p53, ER and PR respectively. No association was found between most of pairs. HER2/neu expression significantly related with grade [P= 0.016]. P53 had considerable reverse relation with axillary lymph node involvement and primary distant metastasis [P= 0.010 and P= 0.023, respectively]. A significant association was found between PR and lymph node involvement [P= 0.038]. This study present the pattern of prognostic biomarkers in breast cancer for the first time in northeast of Iran and suggests to conduct larger studies regarding other effective variables include demographic ones

Gestational trophoblastic disease with metastasis to kidney. Case report

Choriocarcinoma is the most malignant tumor of the gestational trophoblastic neoplasm. It grows rapidly and metastasizes to the lung liver, brain, and less frequently to the other organs. Renal involvement is rare however we encountered a female patient with metastatic choriocarcinoma of the both kidneys. In this article a young woman with multiple metastases from choriocarcinoma is presented. She suffered from prolonged vaginal bleeding, permanent headache, and fever only five months after her first vaginal delivery. Investigation revealed uterus choriocarcinoma with multiple metastases to lung and liver, brain, and both kidneys. Our patient was treated with chemotherapy, radiotherapy and at the end of these treatment all metastases were cured. After a period of sixty months of treatment in serial follow-up, she is well with no sign of recurrent disease

[Four cases of intraepithelial neoplasia of vulva: case report]

Background and Objective: VIN [Vulval Intraepithelial Neoplasia] is a rare disease that can be observed in young females. In this study, four VIN cases referred to the gynecologic oncology clinic of Ghaem and Omid hospitals [Mashhad] during a year are going to be introduced

Cases: Four patients [Mean age 30 years] suffering from mass and itching vulva referred to our center. All had multifocal lesions. Risk factors such as HIV, STD and smoking showed negative results. Despite not having the possibility of examining HPV infection, two patients had koilocytosis pattern in pathologic examination. No patients had CIN and other related genital cancers. Surgery treatment in the form of local excision during the usage of acetic acid was performed in the operating ward. In two patients, the removed marginal tissue showed positive malignancy results had gone through orthovoltage radiotherapy. The recurrence was observed in one patient after one year who was reoperated in the form of skinning vulvectomy

Conclusion: According to this fact that the major cause of VIN is STD and in more than 80% of patients is HPV infection the decrease in incidence of STD can especially lead to VIN decrease and vulva cancer naturally