[Evaluation of gastric surgery complications and their management in patients hospitalized at Ayatollah Taleghani hospital]

Gastric surgeries are still among the major causes of surgery complications. Study on prevalence of these complications and recognition of their risk factors are strongly needed. To study Gastric surgery complications and strategies for their management in patients hospitalized at Ayatollah Taleghani hospital. In this Cross-sectional study all gastric surgeries at Ayatollah Taleghani hospital between 1994 and 2002 were assessed. Variables were age, sex, type of surgery, indication of surgery, type of complication and management strategy [medical or surgical]. Data were collected from patients' medical records. Indications for surgery were gastric malignancy and neoplasia in 277 patients [59.8%], peptic ulcer in 151 [32.6%], and other causes in 7.6%. The most prevalent surgeries were Billroth II [23%] and total gastrectomy [15%]. The highest level of complications was observed in Billroth II [24%]. Complications of surgery occurred in 42 cases [9%] among those 33 males and 9 females. Except for vagotomy and pyloroplasty, less than 50% of complications needed surgical management. This study showed that the prevalence of gastric surgeries complications is 9%, comparable to those found in other studies. The most prevalent surgeries were Billroth II and total gastrectomy, believed to be associated with relatively higher level of complications

[Evaluation of DNA-content of peritoneal lavage cells by flow cytometry in patients with gasteric cancer]

Gastric cancer is the second common cancer in Iran and it has unfortunately no diagnostic signs in early stages. Considering the role of genetic and environmental factors in the development of gastric cancer, this study aimed at evaluating DNA-content of stomach cells in patients with gastric cancer in order to find a reliable index for prediction of disease prognosis and providing more exact therapeutic procedure. A total of 22 samples taken from patients with gastric cancer were evaluated. Peritoneal lavage cells were centrifuged and stained with DNA-staining kit. Then DNA-content was analyzed and compared with that in normal cells by employing flow cytometry and using modfit software. In whole, 12 out of 22 samples were positive and DNA aneuploidy was present in 33.3%. SPF increase was observed in 22.2% of positive cases. SPF can be used as a reliable indicator in pathological staging of cancer and consequently in decision making for treatment

Giant adrenal myelolipoma associated with beta-thalassemia: a case report

Adrenal myelolipomas are rare benign tumors composed of mature adipose tissue and hematopoietic elements that resemble bone marrow. They most commonly occur in the adrenal gland, yet only comprise about 3% of all adrenal tumours. Although several hypotheses have been proposed as to the cause of myelolipoma, the causative process is still not clearly understood. The majority of myelolipomas are asymptomatic. It usually represents as accidental finding in imaging studies. There are some case reports about coincidence of adrenal giant myelolipoma with RBC disorders. In this case report, we present a beta thalassemic 26 year old male patient who had giant adrenal myelolipoma

Long term effects of kidney donation on blood pressure and kidney function of donors

Kidney transplantation from a live donor has many advantages, but the donor should undergo a major surgery and accept potential morbidity and mortality. In this study, we evaluated the long term effects of nephrecetomy on renal function and blood pressure of kidney donors. In this cross-sectinal study, we assessed 195 kidney donors. The controls were 100 healthy individuals with two kidneys. The variables were age, sex, systolic blood pressure [SBP], diastolic blood pressure [DBP], serum creatinine, creatinine clearance and proteinuria [all before and after kidney donation] and time interval between donation and study. Data analysis was accomplished using SPSS software, and paired t-test and Pearson correlation coefficient were used for data analysis. Although serum creatinine was elevated at the time of study, but this rise was not significant. SBP at the time of study was significantly greater than the time of donation [P<0.001]. Creatinine clearance at the time of study was significantly lower than the time of donation [P<0.001]. There was no correlation between serum creatinine, creatinine clearance, SBP, DBP and age at the time of kidney donation in men. Age at the time of kidney donation was correlated with SBP and DBP and creatinine changes in women [P=0.001 and P=0.002, respectively]. This study showed that nephrectomy does not impair renal function in donor and does not lead to a progressive rise in blood pressure or urine protein excretion up to 6.5 years after nephrectomy. Nevertheless, we suggest that kidney donors should be selected after exact screening for potential risk factors of renal disease

[Accuracy assessment of FNA in diagnosis of palpable breast mass]

Due to widespread of palpable breast masses in female and common complications resulted from delayed diagnosis and also with some regards to contradictory reports upon the accuracy of fine needle aspiration [FNA] in comparison with standard method of excisional biopsy this study has been performed on patients with palpable breast mass referred to the Aayatollah Talegheni Hospital between years 2003 and 2005. The present study was based on evaluation of diagnostic methods. Seventy five patients were included in this research and the mean of their age was 44 +/- 10 years [ranged from 20 to 75 years]. FNA was accomplished initially by skin prep with alcohol and holding the lumps between thumb and point fingers. After the needle [No 22-25] was placed into the lump, a continous suction was generated using a 10 ml syring and then multiple in and out needle motions were performed. The collected samples were then smeared on glass slides and allowed to dry out in air and fixed by 96% alcohol. The fixed smears were then stained and examined by a pathologist. Lesions with cystic character were drained and excluded from the study. FNA results were reported according to the latest classification of breast masses as follow c1: inadequate sample, c2: benign, c3: semibenign, c4: semimalignant, c5: malignant [c3 and c4 assumed as indeterminate group]. The total efficiency of FNA for detection of palpable and malignant breast tumor was determined based on, the pathology reports on excisional biopsy [as a gold standard method], the level of sensitivity and specificity, positive and negative predictive values, and also the overall efficiency of FNA. .4 cases of drained cystic lump were eliminated from the study. The amount of sample were inadequate for FNA study in 11 biopsy cases [14.7%]. Nine biopsies [15%] were identified as indeterminate, 43.3% as benign, and 41.7% malignant, which were compatible with the results of excisional biopsy. Therefore 100% [all] of the positive and negative predictive values were obtained. The FNA is a suitable method for diagnosis of malignancy in palpable breast tumor, and hense it can be recommended for this purpose

[Consideration of relation between CEA amount and stage of colorectal cancer in patients referred to Taleghani in 2005-2006]

Background: evaluation of association between CEA amount and stage of colorectal cancer and answer to this question: If CEA amount increases appropriately with stage progression?

Materials and Methods: this descriptive research was performed on 120patients with colorectal cancer, who were admitted in Taleghani hospital from beginning to end of the year 1384. The necessary information was gathered through questionnaire and evaluated by spss program [version 11.5]

Results: aquired information showed that in stage D, in most cases, CEA amount was more than 100 ng/ml which means 30 times more than normal range, but in other stages of disease was no significant correlation between CEA amount and stage

Conclusion: about association between CEA and stage of colorectal cancer, which was the major goal of this research, information show that in the most of cases [ 66,6%] in stage D, CEA amount was 30 times more than normal range, but in other stages of desease was no significant correlation between CEA amount and stage. So CEA amount lonely can't be definite presentative for rate of progression of disease. Although amount of more than 100 ng/ml will probably express metastasis of colorectal cancer [stage D]