RESUMO
Piroxicam is an effective anti- inflammatory agent; it is an inhibitor of prostaglandin biosynthesis. The Principal advantage of Piroxicam is its long half-life, which permits the administration of a single daily dose. Piroxicam is approved in the United States for the treatment of rheumatoid arthritis and osteoarthritis. It has been also used in the treatment of Ankylosing Spondylitis, acute musculoskeletal disorders, dysmenorrhoea, postoperative pain and acute gout. Therefore, patients with gastrointestinal disorders or after surgery often have difficulties taking drugs by mouth. Rectal administration may be a good alternative to oral administration in these types of situations. Therefore in the present research work, attempt has been made to formulate piroxicam suppository dosage form in Witepsol base. In the present study, the effectiveness of different agents on dissolution and release rate of piroxicam from its suppository base has been studied. Also, the effect of propylene glycol as cosolvent, polysorbate 80 as increasing solubility and colloidal silicon dioxide as suspending agent on the release behaviour were investigated. Finally, the best formulation was chosen regarding their release profile, the time needed for 75% release of the drug [t[75]], and uniformity of formulations