RESUMO
Improving quality of life in a chronic disease such as hemophilia is a major goal of treatment. Hemophilic patients can be treated either prophylactically or on demand. Since haemophilia quality of life may be affected by the disease and treatment outcomes, comparison of these regimens in respect to quality of life outcomes provides useful information. The purpose of this study is to compare the quality of life between hemophilic children receiving prophylactic and on demand therapy in Tehran, Iran. A descriptive -comparative design was used. The sample of the study consisted of 60 hemophilic children which were recruited from haemophilia treatment centres in Tehran. Of these children 30 were receiving prophylactic therapy and 30 of them were treated on-demand .Data was collected by haemophilia-specific QoL questionnaire [HAEMO-QoL]. The questionnaire consists of 8 dimensions: physical health, feeling, view of yourself, family, friends, others, sport and dealing with haemophilia.The questionnaire consists of 18 items using a5-point scale.The Higher scores represent a poorer quality of life and lower scores represent better quality of life. Data were analyzed by SPSS 15 statistical software. The mean age of children was 5.3 +/- 1.2 and 6 +/- 1 in prophylactic and on demand therapy respectively. The mean total score of quality of life was 40 +/- 9.8 and 58 +/- 10.9 for children in prophylactic therapy and on-demand treatment respectively. There was a significant difference between the quality of life scores in two groups. Analysis of subscale scores showed a lower quality of life score for family domain in prophylactic therapy group, while the scores for family and physical health subscsles in on-demand group showed a poor quality of life. Results of the study suggest that quality-of-life may be better for haemophilia children treated prophylactically
RESUMO
Pulmonary tuberculosis [TB] is a common worldwide lung infection. It remains an important cause of morbidity and mortality. Radiographic manifestations of pulmonary tuberculosis are diverse and varied. This study was performed to define the various radiographic manifestations of this infection in the pediatric age group in children who were referred to Mofid Children's Hospital. We reviewed chest x-rays of 30 pulmonary TB patients admitted to our hospital to ascertain the extent of parenchymal and mediastinal involvements on chest xray. Male to female ratio was 1.7:1. The patients' age ranged from 2-163 months with a mean age of 36.9 months. Mediastinal lymphadenopathy was detected in 90% of the cases and pulmonary involvement, especially alveolar shadowing was seen in 83.3% of the cases [of which 43.3% had an air-space pattern and 40% had an interstitial pattern]. 19 of the 30 patients [66.3%] were under 36 months, in which 17 of the 19 patients [89.5%] revealed lymphadenopathy. Therefore 63% of all detected lymphadenopathies were seen in this age group. Mediastinal lymphadenopathy was more common on the right side [73.3%]. Furthermore, 60% of all alveolar infiltrations were seen on the right side. Pulmonary tuberculosis most commonly represents as a mediastinal and thereafter as a parenchymal involvement. Hilo-mediastinal lymphadenopathy is the most common presentation in infants and young children